Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability - Wikidata - awgldk - TriplyDB

Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability

Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability

http://www.wikidata.org/entity/Q24669831

about

Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis Genotype-phenotype correlations in non-Finnish congenital nephrotic syndrome Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1 Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin Drosophila tools and assays for the study of human diseases Roles of adaptor proteins in podocyte biology The function of endocytosis in podocytes Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis Solution structure analysis of cytoplasmic domain of podocyte protein Neph1 using small/wide angle x-ray scattering (SWAXS)Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex Slit diaphragms contain tight junction proteins Large-scale identification of genes implicated in kidney glomerulus development and function.Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization.Comparative analysis of Neph gene expression in mouse and chicken development Sns and Kirre, the Drosophila orthologs of Nephrin and Neph1, direct adhesion, fusion and formation of a slit diaphragm-like structure in insect nephrocytes.The glomerular transcriptome and a predicted protein-protein interaction network.Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release.Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography.Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome.Functional study of mammalian Neph proteins in Drosophila melanogaster Nephrotic syndrome: components, connections, and angiopoietin-like 4-related therapeutics Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome.An in vivo functional analysis system for renal gene discovery in Drosophila pericardial nephrocytes The proteinuria-hypertriglyceridemia connection as a basis for novel therapeutics for nephrotic syndrome.Pathophysiologic implications of reduced podocyte number in a rat model of progressive glomerular injury.A plasminogen activator inhibitor type 1 mutant retards diabetic nephropathy in db/db mice by protecting podocytes Role of the podocyte in proteinuria.p47(phox) contributes to albuminuria and kidney fibrosis in mice.CXCL16 and oxLDL are induced in the onset of diabetic nephropathy.Progress in pathogenesis of proteinuria.Dynamin-mediated Nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells.Kin of IRRE-like Protein 2 Is a Phosphorylated Glycoprotein That Regulates Basal Insulin Secretion.A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population.Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm.Nephrin binds to the COOH terminus of a large-conductance Ca2+-activated K+ channel isoform and regulates its expression on the cell surface.

P2860

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P2860

Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability

http://www.wikidata.org/entity/Q24669831

description

2003 nî lūn-bûn

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2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հուլիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Neph1 and nephrin interaction ...... ant of glomerular permeability

@ast

Neph1 and nephrin interaction ...... ant of glomerular permeability

@en

Neph1 and nephrin interaction ...... ant of glomerular permeability

@nl

type

label

Neph1 and nephrin interaction ...... ant of glomerular permeability

@ast

Neph1 and nephrin interaction ...... ant of glomerular permeability

@en

Neph1 and nephrin interaction ...... ant of glomerular permeability

@nl

prefLabel

Neph1 and nephrin interaction ...... ant of glomerular permeability

@ast

Neph1 and nephrin interaction ...... ant of glomerular permeability

@en

Neph1 and nephrin interaction ...... ant of glomerular permeability

@nl

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P932

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P1433

Journal of Clinical Investigation

P1476

Neph1 and nephrin interaction ...... ant of glomerular permeability

@en

P2093

Beenu Kaw

http://www.w3.org/2001/XMLSchema#string

Gang Liu

http://www.w3.org/2001/XMLSchema#string

Jayson Kurfis

http://www.w3.org/2001/XMLSchema#string

Sumant S Chugh

http://www.w3.org/2001/XMLSchema#string

Syed Rahmanuddin

http://www.w3.org/2001/XMLSchema#string

Yashpal S Kanwar

http://www.w3.org/2001/XMLSchema#string

P2860

Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome

NEPH1 defines a novel family of podocin interacting proteins

Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN

NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome

Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis

Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1

The cadherin superfamily

The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1

The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis

Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers

P304

209-21

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scholarly article

P356

10.1172/JCI18242

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P433

2

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P478

112

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P577

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P698

12865409

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P932

164293

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