A role for the P-body component GW182 in microRNA function - Wikidata - awgldk - TriplyDB

A role for the P-body component GW182 in microRNA function

A role for the P-body component GW182 in microRNA function

http://www.wikidata.org/entity/Q24669847

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Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54 miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies In vitro reconstitution of the human RISC-loading complex LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing Importance of translation and nonnucleolytic ago proteins for on-target RNA interference Phosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fate Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system Structural features of Argonaute-GW182 protein interactions CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes Kinetic signatures of microRNA modes of action The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity MicroRNA-155 is an Epstein-Barr virus-induced gene that modulates Epstein-Barr virus-regulated gene expression pathways Consensus miRNA expression profiles derived from interplatform normalization of microarray data Sequence context outside the target region influences the effectiveness of miR-223 target sites in the RhoB 3'UTR Enjoy the Silence: The Story of let-7 MicroRNA and Cancer Small silencing RNAs: an expanding universe Deadenylation is a widespread effect of miRNA regulation On the origin and functions of RNA-mediated silencing: from protists to man B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.RNA granules An Emerging Role of micro-RNA in the Effect of the Endocrine Disruptors RNA Binding Proteins in the miRNA Pathway Regulation of mammalian transcription and splicing by Nuclear RNAi MicroRNAs as Important Players in Host-hepatitis B Virus Interactions MicroRNAs: molecular features and role in cancer Mechanisms of deadenylation-dependent decay Horizontal transfer of RNAs: exosomes as mediators of intercellular communication The panorama of miRNA-mediated mechanisms in mammalian cells Mutations in conserved residues of the C. elegans microRNA Argonaute ALG-1 identify separable functions in ALG-1 miRISC loading and target repression siRNA in human cells selectively localizes to target RNA sites The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing Differential expression of microRNAs in different disease states.

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A role for the P-body component GW182 in microRNA function

http://www.wikidata.org/entity/Q24669847

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2005 nî lūn-bûn

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2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

A role for the P-body component GW182 in microRNA function

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A role for the P-body component GW182 in microRNA function

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A role for the P-body component GW182 in microRNA function

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type

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A role for the P-body component GW182 in microRNA function

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A role for the P-body component GW182 in microRNA function

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A role for the P-body component GW182 in microRNA function

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prefLabel

A role for the P-body component GW182 in microRNA function

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A role for the P-body component GW182 in microRNA function

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A role for the P-body component GW182 in microRNA function

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Nature Cell Biology

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A role for the P-body component GW182 in microRNA function

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Fabiola V Rivas

http://www.w3.org/2001/XMLSchema#string

James Wohlschlegel

http://www.w3.org/2001/XMLSchema#string

Jidong Liu

http://www.w3.org/2001/XMLSchema#string

John R Yates

http://www.w3.org/2001/XMLSchema#string

Roy Parker

http://www.w3.org/2001/XMLSchema#string

P2860

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation

A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles

A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies.

A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing.

miRNP:mRNA association in polyribosomes in a human neuronal cell line.

The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

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10.1038/NCB1333

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