An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine
about
Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathwayKank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activationAbelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formationGrb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1Regulation of actin cytoskeleton architecture by Eps8 and Abi1.Wnt Signalling Promotes Actin Dynamics during Axon Remodelling through the Actin-Binding Protein Eps8A MAPK-Driven Feedback Loop Suppresses Rac Activity to Promote RhoA-Driven Cancer Cell InvasionEps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells.Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF)Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientationThe two hats of SOSNovel binding partners and differentially regulated phosphorylation sites clarify Eps8 as a multi-functional adaptorRestricted Arp3 expression in the testis prevents blood-testis barrier disruption during junction restructuring at spermatogenesisSCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progressionABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memoryEps8 controls actin-based motility by capping the barbed ends of actin filamentsLoss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in miceSH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexesIntersectin 1L guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis.Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms.Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing.Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl-induced leukemia.Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cellsChlamydial entry involves TARP binding of guanine nucleotide exchange factors.Cytoskeletal dynamics and spermatogenesis.EPS8 upregulates FOXM1 expression, enhancing cell growth and motilityRegulation of spermiogenesis, spermiation and blood-testis barrier dynamics: novel insights from studies on Eps8 and Arp3.c-Jun N-terminal kinase 2 (JNK2) enhances cell migration through epidermal growth factor substrate 8 (EPS8).High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia.Rac regulates cardiovascular superoxide through diverse molecular interactions: more than a binary GTP switch.The role of Rho GTPase proteins in CNS neuronal migration.Ezrin regulates microvillus morphogenesis by promoting distinct activities of Eps8 proteins.Postsynaptic enrichment of Eps8 at dendritic shaft synapses of unipolar brush cells in rat cerebellum.An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development.Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages.Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.Activity-dependent spine morphogenesis: a role for the actin-capping protein Eps8
P2860
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P2860
An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
An effector region in Eps8 is ...... sed actin-polymerizing machine
@ast
An effector region in Eps8 is ...... sed actin-polymerizing machine
@en
An effector region in Eps8 is ...... sed actin-polymerizing machine
@nl
type
label
An effector region in Eps8 is ...... sed actin-polymerizing machine
@ast
An effector region in Eps8 is ...... sed actin-polymerizing machine
@en
An effector region in Eps8 is ...... sed actin-polymerizing machine
@nl
prefLabel
An effector region in Eps8 is ...... sed actin-polymerizing machine
@ast
An effector region in Eps8 is ...... sed actin-polymerizing machine
@en
An effector region in Eps8 is ...... sed actin-polymerizing machine
@nl
P2093
P2860
P921
P3181
P356
P1476
An effector region in Eps8 is ...... sed actin-polymerizing machine
@en
P2093
A Tocchetti
E Frittoli
G Giardina
I Ponzanelli
L B Areces
P P Di Fiore
P2860
P304
P3181
P356
10.1083/JCB.200103146
P407
P577
2001-09-03T00:00:00Z