about
An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machineCloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1Abi1 is essential for the formation and activation of a WAVE2 signalling complexSra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangementMechanisms through which Sos-1 coordinates the activation of Ras and Rac.Rapid Remodeling of Invadosomes by Gi-coupled Receptors: DISSECTING THE ROLE OF Rho GTPases.SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeletonProteomic analyses uncover a new function and mode of action for mouse homolog of Diaphanous 2 (mDia2)Regulation of actin dynamics by WASP and WAVE family proteins.Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.Invadosomes - shaping actin networks to follow mechanical cues.New nuclear and perinuclear functions of formins.Flat clathrin lattices are dynamic actin-controlled hubs for clathrin-mediated endocytosis and signalling of specific receptors.PFA fixation enables artifact-free super-resolution imaging of the actin cytoskeleton and associated proteinsCDC25(Mm)/Ras-GRF1 regulates both Ras and Rac signaling pathways.Knockout of the Arp2/3 complex in epidermis causes a psoriasis-like disease hallmarked by hyperactivation of transcription factor Nrf2.Quantitative Proteomics Illuminates a Functional Interaction between mDia2 and the Proteasome.New insights into the formation and the function of lamellipodia and ruffles in mesenchymal cell migration.Initiation of lamellipodia and ruffles involves cooperation between mDia1 and the Arp2/3 complex.WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2.Interplay between N-WASP and CK2 optimizes clathrin-mediated endocytosis of EGFR.CLIC4 is regulated by RhoA-mDia2 signaling through Profilin-1 binding to modulate filopodia lengthAbi1 regulates the activity of N-WASP and WAVE in distinct actin-based processesWASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptorProfilin 1 binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formationThe chloride intracellular channel protein CLIC4 inhibits filopodium formation induced by constitutively active mutants of formin mDia2
P50
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P50
description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Metello Innocenti
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Metello Innocenti
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Metello Innocenti
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Metello Innocenti
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Metello Innocenti
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type
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Metello Innocenti
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Metello Innocenti
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Metello Innocenti
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Metello Innocenti
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Metello Innocenti
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Metello Innocenti
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Metello Innocenti
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Metello Innocenti
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Metello Innocenti
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Metello Innocenti
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P106
P1153
7006506682
P21
P31
P496
0000-0002-7455-2559