The Notch1 receptor is cleaved constitutively by a furin-like convertase - Wikidata - awgldk - TriplyDB

The Notch1 receptor is cleaved constitutively by a furin-like convertase

The Notch1 receptor is cleaved constitutively by a furin-like convertase

http://www.wikidata.org/entity/Q24671866

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AIP4/Itch regulates Notch receptor degradation in the absence of ligand The generation and function of soluble apoE receptors in the CNS SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.Conserved signal peptide of Notch3 inhibits interaction with proteasome The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network Botch promotes neurogenesis by antagonizing Notch The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7 p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling.Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1 Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?Notch-Mediated Cell Adhesion Notch Signaling in Pancreatic Development Targeting Notch to overcome radiation resistance Coordinating tissue interactions: Notch signaling in cardiac development and disease Targeting the Notch signaling pathway in cancer therapeutics Cytokine networking of chondrocyte dedifferentiation in vitro and its implications for cell-based cartilage therapy Toward the structure of presenilin/γ-secretase and presenilin homologs Golgi defects enhance APP amyloidogenic processing in Alzheimer's disease Force-induced unfolding simulations of the human Notch1 negative regulatory region: possible roles of the heterodimerization domain in mechanosensing Structural basis for autoinhibition of Notch A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2 Delta-Notch signalling in segmentation The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods Novel insights into cadherin processing by subtilisin-like convertases Notch ligand endocytosis: mechanistic basis of signaling activity Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation

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P2860

The Notch1 receptor is cleaved constitutively by a furin-like convertase

http://www.wikidata.org/entity/Q24671866

description

1998 nî lūn-bûn

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1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի հուլիսին հրատարակված գիտական հոդված

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1998年の論文

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年學術文章

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name

The Notch1 receptor is cleaved constitutively by a furin-like convertase

@ast

The Notch1 receptor is cleaved constitutively by a furin-like convertase

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The Notch1 receptor is cleaved constitutively by a furin-like convertase

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type

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The Notch1 receptor is cleaved constitutively by a furin-like convertase

@ast

The Notch1 receptor is cleaved constitutively by a furin-like convertase

@en

The Notch1 receptor is cleaved constitutively by a furin-like convertase

@nl

prefLabel

The Notch1 receptor is cleaved constitutively by a furin-like convertase

@ast

The Notch1 receptor is cleaved constitutively by a furin-like convertase

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The Notch1 receptor is cleaved constitutively by a furin-like convertase

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Proceedings of the National Academy of Sciences of the United States of America

P1476

The Notch1 receptor is cleaved constitutively by a furin-like convertase

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P2093

A Israël

http://www.w3.org/2001/XMLSchema#string

C Bessia

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C Brou

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F Logeat

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N G Seidah

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O LeBail

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S Jarriault

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P2860

Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines

Brefeldin A: insights into the control of membrane traffic and organelle structure

Signalling downstream of activated mammalian Notch

A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells

The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

Notch signaling

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

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14

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13631933

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9653148

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