Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation - Wikidata - awgldk - TriplyDB

Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation

Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation

http://www.wikidata.org/entity/Q24671965

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Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs The Heterochromatin Protein 1 family Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1 The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells Regulation of E2F1 function by the nuclear corepressor KAP1 Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1 In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei Stringent doxycycline-dependent control of gene activities using an episomal one-vector system.TRIM28 as a novel transcriptional elongation factor Getting the genome in shape: the formation of loops, domains and compartments The epigenome: the next substrate for engineering PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1 The KRAB zinc finger protein RSL1 regulates sex- and tissue-specific promoter methylation and dynamic hormone-responsive chromatin configuration Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling A proximal activator of transcription in epithelial-mesenchymal transition Embryonic stem cells use ZFP809 to silence retroviral DNAs Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes Paucity and preferential suppression of transgenes in late replication domains of the D. melanogaster genome.Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B.From silencing to gene expression: real-time analysis in single cells Dynamics of epigenetic regulation at the single-cell level.DNA methylation supports intrinsic epigenetic memory in mammalian cells.High-resolution mapping reveals links of HP1 with active and inactive chromatin components.Drosophila SETDB1 is required for chromosome 4 silencing POF and HP1 bind expressed exons, suggesting a balancing mechanism for gene regulation INCURVATA2 encodes the catalytic subunit of DNA Polymerase alpha and interacts with genes involved in chromatin-mediated cellular memory in Arabidopsis thaliana.Adaptive evolution in zinc finger transcription factors.The impact of local genome sequence on defining heterochromatin domains.Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development.The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution associated with unique expression profiles in human tissues.Induction of 11β-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells.

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P2860

Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation

http://www.wikidata.org/entity/Q24671965

description

2003 nî lūn-bûn

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2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2003 թվականի օգոստոսին հրատարակված գիտական հոդված

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Regulated recruitment of HP1 t ...... ture model of gene variegation

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Regulated recruitment of HP1 t ...... ture model of gene variegation

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Regulated recruitment of HP1 t ...... ture model of gene variegation

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David C Schultz

http://www.w3.org/2001/XMLSchema#string

Frank J Rauscher

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Gerd G Maul

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Kasirajan Ayyanathan

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Kazuhiro Tanaka

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Kiyoyuki Torigoe

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Mark S Lechner

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Peter Bell

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Yoshihiko Yamada

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P2860

KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.

Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions

Translating the Histone Code

Regulation of chromatin structure by site-specific histone H3 methyltransferases

HP1gamma associates with euchromatin and heterochromatin in mammalian nuclei and chromosomes

KAP-1, a novel corepressor for the highly conserved KRAB repression domain

Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential

Krüppel-associated boxes are potent transcriptional repression domains

Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD

Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene

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1855-69

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2238957

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10.1101/GAD.1102803

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15

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17

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6531200

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12869583

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196232

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