Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms
about
The current state of eukaryotic DNA base damage and repairUracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvementBase excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracilDifferential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutationBase excision repairFurther evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination.Characterization of DNA glycosylase activity by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stressUracil in DNA and its processing by different DNA glycosylasesEffect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.Phylogenomic analysis of the uracil-DNA glycosylase superfamilyUNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.Unique mutational profile associated with a loss of TDG expression in the rectal cancer of a patient with a constitutional PMS2 deficiencyAssociation of the DNA repair SMUG1 rs3087404 polymorphism and its interaction with high sensitivity C-reactive protein for age-related macular degeneration in Iranian patients.Dependence of antibody gene diversification on uracil excision.Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukarya.Detection of uracil within DNA using a sensitive labeling method for in vitro and cellular applications.Base excision repair, aging and health span.Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese populationEstablishing a model for assessing DNA damage in murine brain cells as a molecular marker of chemotherapy-associated cognitive impairment.Brain capacity for repair of oxidatively damaged DNA and preservation of neuronal function.DNA base repair--recognition and initiation of catalysis.Recognition of damaged DNA: structure and dynamic markers.A unique uracil-DNA binding protein of the uracil DNA glycosylase superfamily.Arabidopsis uracil DNA glycosylase (UNG) is required for base excision repair of uracil and increases plant sensitivity to 5-fluorouracil.Base excision repair enzymes protect abasic sites in duplex DNA from interstrand cross-linksUracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.DNA-N-glycosylases process novel O-glycosidic sites in DNA.Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate.Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1.Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells.Pre-steady-state kinetic analysis of damage recognition by human single-strand selective monofunctional uracil-DNA glycosylase SMUG1.Displacement of SMUG1 glycosylase by APEX1 at the AP siteIdentification of a prototypical single-stranded uracil DNA glycosylase from Listeria innocua.Single-nucleotide polymorphisms of uracil-processing genes affect the occurrence and the onset of recurrent depressive disorder.
P2860
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P2860
Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms
description
2007 nî lūn-bûn
@nan
2007 թուականին հրատարակուած գիտական յօդուած
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2007 թվականին հրատարակված գիտական հոդված
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2007年の論文
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2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
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2007年論文
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2007年论文
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name
Uracil-DNA glycosylases SMUG1 ...... repair by distinct mechanisms
@ast
Uracil-DNA glycosylases SMUG1 ...... repair by distinct mechanisms
@en
Uracil-DNA glycosylases SMUG1 ...... repair by distinct mechanisms
@nl
type
label
Uracil-DNA glycosylases SMUG1 ...... repair by distinct mechanisms
@ast
Uracil-DNA glycosylases SMUG1 ...... repair by distinct mechanisms
@en
Uracil-DNA glycosylases SMUG1 ...... repair by distinct mechanisms
@nl
prefLabel
Uracil-DNA glycosylases SMUG1 ...... repair by distinct mechanisms
@ast
Uracil-DNA glycosylases SMUG1 ...... repair by distinct mechanisms
@en
Uracil-DNA glycosylases SMUG1 ...... repair by distinct mechanisms
@nl
P2093
P2860
P356
P1476
Uracil-DNA glycosylases SMUG1 ...... repair by distinct mechanisms
@en
P2093
Bodil Kavli
Henrik Sahlin Pettersen
Karin Margaretha Gilljam
Ottar Sundheim
P2860
P304
P356
10.1093/NAR/GKM372
P407
P577
2007-01-01T00:00:00Z