Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis
about
Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosisProtein phosphatases and Alzheimer's diseaseA vitellogenin polyserine cleavage site: highly disordered conformation protected from proteolysis by phosphorylationProteolytic activation of ETK/Bmx tyrosine kinase by caspasesTargeting of the transcription factor Max during apoptosis: phosphorylation-regulated cleavage by caspase-5 at an unusual glutamic acid residue in position P1Deconstructing honeybee vitellogenin: novel 40 kDa fragment assigned to its N terminus.An unbiased proteomic screen reveals caspase cleavage is positively and negatively regulated by substrate phosphorylationCaspases and neurodegeneration: on the cutting edge of new therapeutic approaches.Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.Neurons bearing presenilins: weapons for defense or suicide?Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.Presenilin function and gamma-secretase activity.Vital functions for lethal caspases.Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cellsPhosphorylation of the transcription factor YY1 by CK2α prevents cleavage by caspase 7 during apoptosis.The Role of Presenilin-1 in the Excitotoxicity of Ethanol Withdrawal.Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.Twenty Years of Presenilins--Important Proteins in Health and Disease.Phosphorylation of amyloid-β peptide at serine 8 attenuates its clearance via insulin-degrading and angiotensin-converting enzymes.Presenilin-1 is an unprimed glycogen synthase kinase-3beta substrate.The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis.Suppression of the caspase cleavage of beta-amyloid precursor protein by its cytoplasmic phosphorylation.Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis.Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system.A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells.Effect of caspase cleavage-site phosphorylation on proteolysis.Effects of phosphocreatine on apoptosis in a cell-free system.Regulation of lens connexin 45.6 by apoptotic protease, caspase-3.The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart.An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets.Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway.Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo.The relationship between cholesterol level and Alzheimer's disease-associated APP proteolysis/Aβ metabolism.The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.Amyloid beta-induced neuronal death is bax-dependent but caspase-independent.The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.
P2860
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P2860
Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis
description
1999 nî lūn-bûn
@nan
1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Phosphorylation of presenilin- ...... tards progression of apoptosis
@ast
Phosphorylation of presenilin- ...... tards progression of apoptosis
@en
Phosphorylation of presenilin- ...... tards progression of apoptosis
@nl
type
label
Phosphorylation of presenilin- ...... tards progression of apoptosis
@ast
Phosphorylation of presenilin- ...... tards progression of apoptosis
@en
Phosphorylation of presenilin- ...... tards progression of apoptosis
@nl
prefLabel
Phosphorylation of presenilin- ...... tards progression of apoptosis
@ast
Phosphorylation of presenilin- ...... tards progression of apoptosis
@en
Phosphorylation of presenilin- ...... tards progression of apoptosis
@nl
P2093
P2860
P356
P1476
Phosphorylation of presenilin- ...... tards progression of apoptosis
@en
P2093
A Schindzielorz
J Grünberg
P2860
P304
P356
10.1073/PNAS.96.4.1391
P407
P577
1999-02-16T00:00:00Z