Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis.
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Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease.Protein phosphatases and Alzheimer's diseaseProtease regulation: the Yin and Yang of neural development and diseaseExtracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain sheddingPathogenic PS1 phosphorylation at Ser367Bidirectional regulation of Aβ levels by Presenilin 1.Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin.An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum.The Role of Presenilin-1 in the Excitotoxicity of Ethanol Withdrawal.Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.Protein Phosphorylation is a Key Mechanism in Alzheimer's Disease.Phosphorylation of amyloid-β peptide at serine 8 attenuates its clearance via insulin-degrading and angiotensin-converting enzymes.γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.Presenilin-1 is an unprimed glycogen synthase kinase-3beta substrate.Caspase cleaved presenilin-1 is part of active gamma-secretase complexes.Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment.Suppression of the caspase cleavage of beta-amyloid precursor protein by its cytoplasmic phosphorylation.γ-Secretase in microglia - implications for neurodegeneration and neuroinflammation.Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo.The relationship between cholesterol level and Alzheimer's disease-associated APP proteolysis/Aβ metabolism.Effect of gestational protein deficiency and excess on hepatic expression of genes related to cell cycle and proliferation in offspring from late gestation to finishing phase in pig.
P2860
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P2860
Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Phosphorylation of presenilin ...... the progression of apoptosis.
@en
type
label
Phosphorylation of presenilin ...... the progression of apoptosis.
@en
prefLabel
Phosphorylation of presenilin ...... the progression of apoptosis.
@en
P2860
P50
P356
P1476
Phosphorylation of presenilin ...... the progression of apoptosis.
@en
P2093
Arno Friedlein
Jochen Walter
P2860
P304
P356
10.1074/JBC.M306653200
P407
P577
2003-10-22T00:00:00Z