The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo
about
A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling.The ESCRT-associated protein Alix recruits the ubiquitin ligase Nedd4-1 to facilitate HIV-1 release through the LYPXnL L domain motifCalcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibitionWrapping up the bad news: HIV assembly and releaseStructural Basis of Membrane Targeting by the Dock180 Family of Rho Family Guanine Exchange Factors (Rho-GEFs)Dual sorting of the Saccharomyces cerevisiae vacuolar protein Sna4p.Characterization of multiple multivesicular body sorting determinants within Sna3: a role for the ubiquitin ligase Rsp5.Ubp2 regulates Rsp5 ubiquitination activity in vivo and in vitro.Characterization of yeast mutants lacking alkaline ceramidases YPC1 and YDC1.Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodiesInteraction of the deubiquitinating enzyme Ubp2 and the e3 ligase Rsp5 is required for transporter/receptor sorting in the multivesicular body pathway.Overexpression of Sna3 stabilizes tryptophan permease Tat2, potentially competing for the WW domain of Rsp5 ubiquitin ligase with its binding protein Bul1.Transferrin receptor-like proteins control the degradation of a yeast metal transporterSUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p.Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway.Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress.G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase.Regulation of clathrin-mediated endocytosis by dynamic ubiquitination and deubiquitination.Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2Synaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent mannerGβ promotes pheromone receptor polarization and yeast chemotropism by inhibiting receptor phosphorylationNovel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodiesWUSCHEL-responsive At5g65480 interacts with CLAVATA components in vitro and in transient expression.The HECT domain of the ubiquitin ligase Rsp5 contributes to substrate recognitionPolarization of the yeast pheromone receptor requires its internalization but not actin-dependent secretionA splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila.Expression-based and co-localization detection of arabinogalactan protein 6 and arabinogalactan protein 11 interactors in Arabidopsis pollen and pollen tubesAmino acids regulate retrieval of the yeast general amino acid permease from the vacuolar targeting pathway.Versatile roles of k63-linked ubiquitin chains in trafficking.gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway.Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking.Molecular mechanisms of ubiquitin-dependent membrane trafficPI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signalSplit-ubiquitin two-hybrid assay to analyze protein-protein interactions at the endosome: application to Saccharomyces cerevisiae Bro1 interacting with ESCRT complexes, the Doa4 ubiquitin hydrolase, and the Rsp5 ubiquitin ligase.A dual role for K63-linked ubiquitin chains in multivesicular body biogenesis and cargo sortingE3 ubiquitin ligases as regulators of membrane protein trafficking and degradation.Targeting of Sna3p to the endosomal pathway depends on its interaction with Rsp5p and multivesicular body sorting on its ubiquitylation
P2860
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P2860
The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The C2 domain of the Rsp5 ubiq ...... quitination of endosomal cargo
@ast
The C2 domain of the Rsp5 ubiq ...... quitination of endosomal cargo
@en
The C2 domain of the Rsp5 ubiq ...... quitination of endosomal cargo
@nl
type
label
The C2 domain of the Rsp5 ubiq ...... quitination of endosomal cargo
@ast
The C2 domain of the Rsp5 ubiq ...... quitination of endosomal cargo
@en
The C2 domain of the Rsp5 ubiq ...... quitination of endosomal cargo
@nl
prefLabel
The C2 domain of the Rsp5 ubiq ...... quitination of endosomal cargo
@ast
The C2 domain of the Rsp5 ubiq ...... quitination of endosomal cargo
@en
The C2 domain of the Rsp5 ubiq ...... quitination of endosomal cargo
@nl
P2093
P2860
P356
P1476
The C2 domain of the Rsp5 ubiq ...... quitination of endosomal cargo
@en
P2093
Adam S Adler
Deborah A Klos
Linda Hicke
Rebecca Dunn
P2860
P304
P356
10.1083/JCB.200309026
P407
P577
2004-04-01T00:00:00Z