Structural basis for transcription inhibition by tagetitoxin
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Tagetitoxin inhibits RNA polymerase through trapping of the trigger loopActive site opening and closure control translocation of multisubunit RNA polymeraseAn allosteric mechanism of Rho-dependent transcription terminationResponse to Klyuyev and Vassylyev: on the mechanism of tagetitoxin inhibition of transcriptionThe binding site and mechanism of the RNA polymerase inhibitor tagetitoxin: an issue open to debateAn insertion in the catalytic trigger loop gates the secondary channel of RNA polymerase.Central role of the RNA polymerase trigger loop in intrinsic RNA hydrolysis.Molecular basis of RNA polymerase promoter specificity switch revealed through studies of Thermus bacteriophage transcription regulatorRegulation through the RNA polymerase secondary channel. Structural and functional variability of the coiled-coil transcription factors.Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis.Elongation complexes of Thermus thermophilus RNA polymerase that possess distinct translocation conformations.Purification of bacterial RNA polymerase: tools and protocols.Transcription initiation factor DksA has diverse effects on RNA chain elongationStill looking for the magic spot: the crystallographically defined binding site for ppGpp on RNA polymerase is unlikely to be responsible for rRNA transcription regulation.Bacterial Transcription as a Target for Antibacterial Drug Development.RNA polymerase stalls in a post-translocated register and can hyper-translocate.Alu retrotransposons promote differentiation of human carcinoma cells through the aryl hydrocarbon receptor.RNA polymerase active center: the molecular engine of transcription.Macromolecular micromovements: how RNA polymerase translocates.Elongation by RNA polymerase: a race through roadblocks.Prospects for new antibiotics: a molecule-centered perspective.Multiple active centers of multi-subunit RNA polymerases.On the validation of crystallographic symmetry and the quality of structures.The structure of tagetitoxin.Comparative whole genome sequence analysis of wild-type and cidofovir-resistant monkeypoxvirus.Controlled interplay between trigger loop and Gre factor in the RNA polymerase active centre.Activity map of the Escherichia coli RNA polymerase bridge helix.Fidaxomicin is an inhibitor of the initiation of bacterial RNA synthesisAllosteric control of the RNA polymerase by the elongation factor RfaHTagetitoxin inhibits transcription by stabilizing pre-translocated state of the elongation complex.In vitro approaches to analysis of transcription termination.Transcription termination factor rho prefers catalytically active elongation complexes for releasing RNA.Characterization of single and double inactivation strains reveals new physiological roles for group 2 sigma factors in the cyanobacterium Synechocystis sp. PCC 6803.Stereocontrolled synthesis of the oxathiabicyclo[3.3.1]nonane core structure of tagetitoxin.Inorganic phosphate, arsenate, and vanadate enhance exonuclease transcript cleavage by RNA polymerase by 2000-fold.RNA-DNA and DNA-DNA base-pairing at the upstream edge of the transcription bubble regulate translocation of RNA polymerase and transcription rate.Active site closure stabilizes the backtracked state of RNA polymerase
P2860
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P2860
Structural basis for transcription inhibition by tagetitoxin
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Structural basis for transcription inhibition by tagetitoxin
@ast
Structural basis for transcription inhibition by tagetitoxin
@en
Structural basis for transcription inhibition by tagetitoxin
@nl
type
label
Structural basis for transcription inhibition by tagetitoxin
@ast
Structural basis for transcription inhibition by tagetitoxin
@en
Structural basis for transcription inhibition by tagetitoxin
@nl
prefLabel
Structural basis for transcription inhibition by tagetitoxin
@ast
Structural basis for transcription inhibition by tagetitoxin
@en
Structural basis for transcription inhibition by tagetitoxin
@nl
P2093
P2860
P356
P1476
Structural basis for transcription inhibition by tagetitoxin
@en
P2093
Anna Perederina
Dmitry G Vassylyev
Marina N Vassylyeva
Naohiro Matsugaki
Noriyuki Igarashi
Vladimir Svetlov
P2860
P2888
P304
P356
10.1038/NSMB1015
P407
P577
2005-12-01T00:00:00Z
P5875
P6179
1041167547