Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer - Wikidata - awgldk - TriplyDB

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

http://www.wikidata.org/entity/Q24681223

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The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age Connecting the Dots: From DNA Damage and Repair to Aging The mechanism of human nonhomologous DNA end joining Growth conditions that increase or decrease lifespan in Saccharomyces cerevisiae lead to corresponding decreases or increases in rates of interstitial deletions and non-reciprocal translocations The Ink4/Arf locus is a barrier for iPS cell reprogramming Increased insensible water loss contributes to aging related dehydration.Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells Werner syndrome protein positively regulates XRCC4-like factor transcription Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response.Senescent cells: a novel therapeutic target for aging and age-related diseases TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends.The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.DNA repair deficiency in neurodegeneration.Do DNA Double-Strand Breaks Drive Aging?Loss of Nfkb1 leads to early onset aging PTH1-34 blocks radiation-induced osteoblast apoptosis by enhancing DNA repair through canonical Wnt pathway Cellular senescence and organismal ageing in the absence of p21(CIP1/WAF1) in ku80(-/-) mice.Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome The ageing epigenome: damaged beyond repair?Comparison of cytotoxicity and genotoxicity of 4-hydroxytamoxifen in combination with Tualang honey in MCF-7 and MCF-10A cells.Polμ deficiency increases resistance to oxidative damage and delays liver aging.DNA damage and ageing: new-age ideas for an age-old problem Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases.Factors Affecting the Radiosensitivity of Hexaploid Wheat to γ-Irradiation: Radiosensitivity of Hexaploid Wheat (Triticum aestivum L.) [Corrected].Clinical implications of the basic defects in Cockayne syndrome and xeroderma pigmentosum and the DNA lesions responsible for cancer, neurodegeneration and aging Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging Aging and cancer cell biology, 2008.Bax-induced apoptosis shortens the life span of DNA repair defect Ku70-knockout mice by inducing emphysema DNA double-strand breaks: a potential causative factor for mammalian aging?Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production.Knockout of Ku86 accelerates cellular senescence induced by high NaCl.Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair Computational systems biology of aging.Nuclear and mitochondrial DNA repair in selected eukaryotic aging model systems.Convergent adaptation of cellular machineries in the evolution of large body masses and long life spans.Non-homologous end joining: advances and frontiers.Ku80-deleted cells are defective at base excision repair.RB in DNA repair.

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P2860

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

http://www.wikidata.org/entity/Q24681223

description

2007 nî lūn-bûn

@nan

2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

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2007年论文

@wuu

name

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

@ast

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

@en

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

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type

label

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

@ast

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

@en

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

@nl

prefLabel

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

@ast

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

@en

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

@nl

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Molecular and Cellular Biology

P1476

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer

@en

P2093

Han Li

http://www.w3.org/2001/XMLSchema#string

Paul Hasty

http://www.w3.org/2001/XMLSchema#string

Valerie B Holcomb

http://www.w3.org/2001/XMLSchema#string

Yansong Gu

http://www.w3.org/2001/XMLSchema#string

P2860

Isolation of Ku70-binding proteins (KUBs)

Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis

Ku is associated with the telomere in mammals

Interaction of human Ku70 with TRF2

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.

Chromosomal double-strand break repair in Ku80-deficient cells

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8205-8214

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scholarly article

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1803224

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10.1128/MCB.00785-07

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23

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27

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Otto Hannes Vogel

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2007-09-17T00:00:00Z

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5966962

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17875923

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2169178

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