Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig - Wikidata - awgldk - TriplyDB

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

http://www.wikidata.org/entity/Q24683936

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REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis Liver x receptors in atherosclerosis and inflammation Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses 24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins Current trends in oxysterol research Armand-Frappier Outstanding Student Award--The emerging role of 25-hydroxycholesterol in innate immunity Molecular pathways for intracellular cholesterol accumulation: common pathogenic mechanisms in Niemann-Pick disease Type C and cystic fibrosis Dual functions of Insig proteins in cholesterol homeostasis Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183)OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages The dynamin chemical inhibitor dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2 Zinc finger transcription factors displaced SREBP proteins as the major Sterol regulators during Saccharomycotina evolution Regulation of sterol regulatory element-binding transcription factor 1a by human chorionic gonadotropin and insulin in cultured rat theca-interstitial cells The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors Sterol Regulatory Element-Binding Proteins (SREBP) signalling PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.Side-chain oxysterols: from cells to membranes to molecules.Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex.Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling.ER stress and hepatic lipid metabolism.Sterol regulatory element-binding proteins are regulators of the NIS gene in thyroid cells.Oxysterols and their cellular effectors.Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi.Sterol regulatory element binding proteins in fungi: hypoxic transcription factors linked to pathogenesis INSIG1 influences obesity-related hypertriglyceridemia in humans.24S,25-Epoxycholesterol in mouse and rat brain.Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62 Whole exome sequencing of familial hypercholesterolaemia patients negative for LDLR/APOB/PCSK9 mutations miR-33 links SREBP-2 induction to repression of sterol transporters.Obesity, cholesterol metabolism, and breast cancer pathogenesis Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages Cell cholesterol homeostasis: mediation by active cholesterol Scientific side trips: six excursions from the beaten path.Insights into the mechanisms of sterol transport between organelles.

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Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

http://www.wikidata.org/entity/Q24683936

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2007 nî lūn-bûn

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2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2007 թվականի ապրիլին հրատարակված գիտական հոդված

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2007年の論文

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Proceedings of the National Academy of Sciences of the United States of America

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Sterol-regulated transport of ...... transport by binding to Insig

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Hyock Joo Kwon

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Michael S Brown

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Yukio Ikeda

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P2860

Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

Structural mechanism for sterol sensing and transport by OSBP-related proteins.

Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis

Do oxysterols control cholesterol homeostasis?

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

Oxysterol biosynthetic enzymes

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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10.1073/PNAS.0700899104

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16

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104

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Joseph L. Goldstein

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endoplasmic reticulum

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