Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.
about
Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism.Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structureSynaptic Plasticity, a Prominent Contributor to the Anxiety in Fragile X SyndromeMouse Genetic Models of Human Brain DisordersModulation of actin dynamics by Rac1 to target cognitive functionSynaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia.Fragile X syndrome and targeted treatment trials.Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us.The pathophysiology of fragile X (and what it teaches us about synapses)Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromesFragile X-like behaviors and abnormal cortical dendritic spines in cytoplasmic FMR1-interacting protein 2-mutant mice.Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and BackThe Intense World Theory – A Unifying Theory of the Neurobiology of AutismA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.PAK in Alzheimer disease, Huntington disease and X-linked mental retardationPAK signalling during the development and progression of cancerPAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence.A FOXO-Pak1 transcriptional pathway controls neuronal polarityp21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesisRescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampusBehavioural phenotyping assays for mouse models of autismSelective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.From FMRP function to potential therapies for fragile X syndrome.Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model.Arf6-GEF BRAG1 regulates JNK-mediated synaptic removal of GluA1-containing AMPA receptors: a new mechanism for nonsyndromic X-linked mental disorder.Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autismThe autism diagnosis in translation: shared affect in children and mouse models of ASD.Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disordersTranslational animal models of autism and neurodevelopmental disorders.The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome.Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders.The clinical-basic interface in defining pathogenesis in disorders of neurodevelopmental origin.EphB receptors couple dendritic filopodia motility to synapse formation.Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse modelAcute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats.Acamprosate in a mouse model of fragile X syndrome: modulation of spontaneous cortical activity, ERK1/2 activation, locomotor behavior, and anxietyFragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells.A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly.
P2860
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P2860
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice
@nl
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.
@ast
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.
@en
type
label
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice
@nl
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.
@ast
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.
@en
prefLabel
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice
@nl
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.
@ast
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.
@en
P2093
P2860
P3181
P356
P1476
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.
@en
P2093
B S Shankaranarayana Rao
Bridget M Dolan
Han-Saem Choi
Jin-Soo Seo
Mansuo L Hayashi
Sumantra Chattarji
P2860
P304
11489-11494
P3181
P356
10.1073/PNAS.0705003104
P407
P577
2007-06-25T00:00:00Z