A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells
about
Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signalingThe TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expressionTargeting BTK with ibrutinib in relapsed chronic lymphocytic leukemiaThe Bruton tyrosine kinase inhibitor ibrutinib with chemoimmunotherapy in patients with chronic lymphocytic leukemia.Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for TecInhibitors of B-cell receptor signaling for patients with B-cell malignancies.Translational hematology.TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS.Different sensitivity of germinal center B cell-like diffuse large B cell lymphoma cells towards ibrutinib treatmentThe safety of Bruton's tyrosine kinase inhibitors for the treatment of chronic lymphocytic leukemia.Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT-199).A kinase independent function for Tec kinase ITK in regulating antigen receptor induced serum response factor activation.Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling.Diverse phosphorylation patterns of B cell receptor-associated signaling in naïve and memory human B cells revealed by phosphoflow, a powerful technique to study signaling at the single cell level.Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes.Regulation of MAPK signaling and implications in chronic lymphocytic leukemia.
P2860
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P2860
A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells
description
2001 nî lūn-bûn
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2001 թուականին հրատարակուած գիտական յօդուած
@hyw
2001 թվականին հրատարակված գիտական հոդված
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2001年の論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年论文
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name
A conditional form of Bruton's ...... ays via PLC Gamma 2 in B cells
@ast
A conditional form of Bruton's ...... ays via PLC Gamma 2 in B cells
@en
A conditional form of Bruton's ...... ays via PLC Gamma 2 in B cells
@nl
type
label
A conditional form of Bruton's ...... ays via PLC Gamma 2 in B cells
@ast
A conditional form of Bruton's ...... ays via PLC Gamma 2 in B cells
@en
A conditional form of Bruton's ...... ays via PLC Gamma 2 in B cells
@nl
prefLabel
A conditional form of Bruton's ...... ays via PLC Gamma 2 in B cells
@ast
A conditional form of Bruton's ...... ays via PLC Gamma 2 in B cells
@en
A conditional form of Bruton's ...... ays via PLC Gamma 2 in B cells
@nl
P2093
P2860
P356
P1433
P1476
A conditional form of Bruton's ...... ays via PLC Gamma 2 in B cells
@en
P2093
J A Johnston
M G Tomlinson
T Kurosaki
P2860
P2888
P356
10.1186/1471-2172-2-4
P407
P577
2001-01-01T00:00:00Z
P5875
P6179
1018894923