Perturbations in the impact of mutational activity on Vlambda genes in systemic lupus erythematosus
about
Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren's syndromeAnalysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren's syndrome.Increased negative selection impairs neonatal B cell repertoire but does not directly lead to generation of disease-associated IgM auto-antibodies.B cells in autoimmune diseases: insights from analyses of immunoglobulin variable (Ig V) gene usage.B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients.CD154-CD40 interactions mediate differentiation to plasma cells in healthy individuals and persons with systemic lupus erythematosus.Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions.AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4An anti-DNA antibody prefers damaged dsDNA over native.
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P2860
Perturbations in the impact of mutational activity on Vlambda genes in systemic lupus erythematosus
description
2001 nî lūn-bûn
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2001 թուականին հրատարակուած գիտական յօդուած
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2001 թվականին հրատարակված գիտական հոդված
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2001年の論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年论文
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Perturbations in the impact of ...... n systemic lupus erythematosus
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Perturbations in the impact of ...... n systemic lupus erythematosus
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Perturbations in the impact of ...... n systemic lupus erythematosus
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Perturbations in the impact of ...... n systemic lupus erythematosus
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Perturbations in the impact of ...... n systemic lupus erythematosus
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Perturbations in the impact of ...... n systemic lupus erythematosus
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Perturbations in the impact of ...... n systemic lupus erythematosus
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Perturbations in the impact of ...... n systemic lupus erythematosus
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10.1186/AR329
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2001-01-01T00:00:00Z
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1038507980