Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage
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Critical pathogenic events underlying progression of neurodegeneration inĀ glaucomaMutations in a P-type ATPase gene cause axonal degenerationMitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degenerationSpink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damageSilencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activitySustained ocular hypertension induces dendritic degeneration of mouse retinal ganglion cells that depends on cell type and location.Early microglia activation in a mouse model of chronic glaucoma.DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma.Involvement of EphB/Ephrin-B signaling in axonal survival in mouse experimental glaucoma.Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucomaProgressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetricDominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice.Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1Inducible nitric oxide synthase, Nos2, does not mediate optic neuropathy and retinopathy in the DBA/2J glaucoma model.Rgcs1, a dominant QTL that affects retinal ganglion cell death after optic nerve crush in mice.Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension.Hyperbaric pressure and increased susceptibility to glutamate toxicity in retinal ganglion cells in vitroDifferential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crushBax-induced apoptosis in Leber's congenital amaurosis: a dual role in rod and cone degeneration.Laser-induced ocular hypertension in albino CD-1 mice.Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma.Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosisWallerian-like axonal degeneration in the optic nerve after excitotoxic retinal insult: an ultrastructural study.Profiles of extracellular miRNAs in the aqueous humor of glaucoma patients assessed with a microarray systemRodent models of glaucoma.The apoptotic response in HCT116BAX-/- cancer cells becomes rapidly saturated with increasing expression of a GFP-BAX fusion proteinEarly immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective.Western blot patterns of serum autoantibodies against optic nerve antigens in dogs with goniodysgenesis-related glaucoma.Early gene expression changes in the retinal ganglion cell layer of a rat glaucoma modelDistal axonopathy with structural persistence in glaucomatous neurodegeneration.A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell deathDLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injuryMetabolic vulnerability disposes retinal ganglion cell axons to dysfunction in a model of glaucomatous degenerationVariations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins.Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice.Inhibition of histone deacetylase protects the retina from ischemic injuryIncreased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma.Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data.Wallerian degeneration, wld(s), and nmnat.DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation.
P2860
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P2860
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage
description
2005 nĆ® lÅ«n-bĆ»n
@nan
2005 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« Õ
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@hyw
2005 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Õ°ÕøÖÕ¬Õ«Õ½Õ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
2005幓ć®č«ę
@ja
2005幓č«ę
@yue
2005幓č«ę
@zh-hant
2005幓č«ę
@zh-hk
2005幓č«ę
@zh-mo
2005幓č«ę
@zh-tw
2005幓č®ŗę
@wuu
name
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage
@ast
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage
@en
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage
@nl
type
label
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage
@ast
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage
@en
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage
@nl
prefLabel
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage
@ast
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage
@en
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage
@nl
P2093
P2860
P3181
P1433
P1476
Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage
@en
P2093
Joseph Barter
Olga V Savinova
Richard S Smith
Richard T Libby
Robert W Nickells
Simon W M John
P2860
P3181
P356
10.1371/JOURNAL.PGEN.0010004
P407
P577
2005-07-01T00:00:00Z