The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA
about
The spectrum of WRN mutations in Werner syndrome patientsRoles of Werner syndrome protein in protection of genome integrityModel of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromesHuman premature aging, DNA repair and RecQ helicasesNucleases in homologous recombination as targets for cancer therapyCrystal structure of bacteriophage T4 5' nuclease in complex with a branched DNA reveals how flap endonuclease-1 family nucleases bind their substratesTim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathwayInteracting partners of FEN1 and its role in the development of anticancer therapeutics.Flap endonuclease 1 mechanism analysis indicates flap base binding prior to threadingPrereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins.The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations.RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and functionHuman RecQ helicases in DNA repair, recombination, and replication.Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stabilityFlap endonuclease 1 contributes to telomere stabilityEvidence for base excision repair processing of DNA interstrand crosslinks.From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1Flap endonuclease 1.Helicases as prospective targets for anti-cancer therapy.The wonders of flap endonucleases: structure, function, mechanism and regulation.Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathwaysDirect and indirect roles of RECQL4 in modulating base excision repair capacity.The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase δ Elongation.Telomere replication: poised but puzzlingNon-B DNA Secondary Structures and Their Resolution by RecQ Helicases.FEN1 ensures telomere stability by facilitating replication fork re-initiationThe Werner syndrome protein is required for recruitment of chromatin assembly factor 1 following DNA damage.Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus.
P2860
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P2860
The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The interaction site of Flap E ...... a coordination of WRN and PCNA
@ast
The interaction site of Flap E ...... a coordination of WRN and PCNA
@en
The interaction site of Flap E ...... a coordination of WRN and PCNA
@nl
type
label
The interaction site of Flap E ...... a coordination of WRN and PCNA
@ast
The interaction site of Flap E ...... a coordination of WRN and PCNA
@en
The interaction site of Flap E ...... a coordination of WRN and PCNA
@nl
prefLabel
The interaction site of Flap E ...... a coordination of WRN and PCNA
@ast
The interaction site of Flap E ...... a coordination of WRN and PCNA
@en
The interaction site of Flap E ...... a coordination of WRN and PCNA
@nl
P2093
P2860
P356
P1476
The interaction site of Flap E ...... a coordination of WRN and PCNA
@en
P2093
Erica Friedrich-Heineken
Joshua A Sommers
Robert M Brosh
Ulrich Hübscher
P2860
P304
P356
10.1093/NAR/GKI1002
P407
P577
2005-12-02T00:00:00Z