Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels.
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Cullin-RING ubiquitin ligases: global regulation and activation cyclesAssociation of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosomeCOP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phaseImpaired DNA damage checkpoint response in MIF-deficient miceCSN controls NF-kappaB by deubiquitinylation of IkappaBalphaThe glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7COP9-associated CSN5 regulates exosomal protein deubiquitination and sortingThe Arabidopsis COP9 Signalosome Subunit 7 Is a Model PCI Domain Protein with Subdomains Involved in COP9 Signalosome AssemblyRegulation of abiotic stress signal transduction by E3 ubiquitin ligases in Arabidopsis.The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae.Neurospora COP9 signalosome integrity plays major roles for hyphal growth, conidial development, and circadian functionCharacterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases.Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stabilityAnalysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagyRole of individual subunits of the Neurospora crassa CSN complex in regulation of deneddylation and stability of cullin proteins.C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissuesRegulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylation site.Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cellsCullin E3 ligases and their rewiring by viral factorsNeddylation and deneddylation in cardiac biologyCSN-mediated deneddylation differentially modulates Ci(155) proteolysis to promote Hedgehog signalling responsesCIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo.Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline.Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development.Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complexStructural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle.Ubiquitin ligases in cancer: ushers for degradation.Macrophage migration inhibitory factor manipulation and evaluation in tumoral hypoxic adaptation.CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer.The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription.CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progressionThe COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resettingTargeted inhibition of the COP9 signalosome for treatment of cancerCRL Ubiquitin Ligases and DNA Damage Response.The F-box protein ACRE189/ACIF1 regulates cell death and defense responses activated during pathogen recognition in tobacco and tomato.Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways.A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.
P2860
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P2860
Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Targeted silencing of Jab1/Csn ...... uction of F-box protein levels
@nl
Targeted silencing of Jab1/Csn ...... ction of F-box protein levels.
@ast
Targeted silencing of Jab1/Csn ...... ction of F-box protein levels.
@en
type
label
Targeted silencing of Jab1/Csn ...... uction of F-box protein levels
@nl
Targeted silencing of Jab1/Csn ...... ction of F-box protein levels.
@ast
Targeted silencing of Jab1/Csn ...... ction of F-box protein levels.
@en
prefLabel
Targeted silencing of Jab1/Csn ...... uction of F-box protein levels
@nl
Targeted silencing of Jab1/Csn ...... ction of F-box protein levels.
@ast
Targeted silencing of Jab1/Csn ...... ction of F-box protein levels.
@en
P2860
P3181
P356
P1433
P1476
Targeted silencing of Jab1/Csn ...... ction of F-box protein levels.
@en
P2093
Gregory A Cope
Raymond J Deshaies
P2860
P2888
P3181
P356
10.1186/1471-2091-7-1
P407
P577
2006-01-09T00:00:00Z
P5875
P6179
1041689398