A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.
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The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaksDVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocksRing of Change: CDC48/p97 Drives Protein Dynamics at ChromatinSignal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97.Ubiquitylation, neddylation and the DNA damage responseCleaning up in the endoplasmic reticulum: ubiquitin in chargeA non-canonical role of the p97 complex in RIG-I antiviral signalingThe UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replicationp97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates.Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity.A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis.Ubiquitin-specific protease 7 regulates nucleotide excision repair through deubiquitinating XPC protein and preventing XPC protein from undergoing ultraviolet light-induced and VCP/p97 protein-regulated proteolysis.Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.Concerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response.Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligaseMitotic UV irradiation induces a DNA replication-licensing defect that potentiates G1 arrest response.Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks.Epidermal growth factor receptor protects proliferating cell nuclear antigen from cullin 4A protein-mediated proteolysis.Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functionsMismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase.Revoking the cellular license to replicate: yet another AAA assignment.Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.Structure and function of the AAA+ ATPase p97/Cdc48p.Role of p97/VCP (Cdc48) in genome stability.A replicator-specific binding protein essential for site-specific initiation of DNA replication in mammalian cells.Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.VBP1 facilitates proteasome and autophagy-mediated degradation of MutS homologue hMSH4.Interaction between salt-inducible kinase 2 (SIK2) and p97/valosin-containing protein (VCP) regulates endoplasmic reticulum (ER)-associated protein degradation in mammalian cells.The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IκBα proteolysis.PIP degron proteins, substrates of CRL4Cdt2, and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damageDNA damage emergency: cellular garbage disposal to the rescue?Flipping the switch from g1 to s phase with e3 ubiquitin ligasesThe 26S proteasome and initiation of gene transcription.The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation.VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair.Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication.CRL2Lrr1 promotes unloading of the vertebrate replisome from chromatin during replication termination.On-site remodeling at chromatin: How multiprotein complexes are rebuilt during DNA repair and transcriptional activation.
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A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
A genome-wide screen identifie ...... ge-dependent CDT1 destruction.
@en
type
label
A genome-wide screen identifie ...... ge-dependent CDT1 destruction.
@en
prefLabel
A genome-wide screen identifie ...... ge-dependent CDT1 destruction.
@en
P2860
P50
P1433
P1476
A genome-wide screen identifie ...... age-dependent CDT1 destruction
@en
P2093
Courtney G Havens
P2860
P356
10.1016/J.MOLCEL.2011.06.036
P577
2011-10-01T00:00:00Z