Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis
about
Origins of amyloid-βSynapses and Alzheimer's diseaseSoluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APPCaenorhabditis elegans as a model organism to study APP functionPlatelets and Alzheimer's disease: Potential of APP as a biomarkerFE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation.Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tauCentral CRF system perturbation in an Alzheimer's disease knockin mouse model.Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow.A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives.APP is phosphorylated by TrkA and regulates NGF/TrkA signaling.Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses.APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice.Biology and pathophysiology of the amyloid precursor protein.APP physiological and pathophysiological functions: insights from animal models.Functions of the APP gene family in the nervous system: insights from mouse models.Physiological functions of APP family proteins.Not just amyloid: physiological functions of the amyloid precursor protein family.APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins.Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and NeurodegenerationDisruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons.APP, APLP2 and LRP1 interact with PCSK9 but are not required for PCSK9-mediated degradation of the LDLR in vivo.
P2860
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P2860
Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Genetic dissection of the amyl ...... ction and amyloid pathogenesis
@ast
Genetic dissection of the amyl ...... ction and amyloid pathogenesis
@en
Genetic dissection of the amyl ...... ction and amyloid pathogenesis
@nl
type
label
Genetic dissection of the amyl ...... ction and amyloid pathogenesis
@ast
Genetic dissection of the amyl ...... ction and amyloid pathogenesis
@en
Genetic dissection of the amyl ...... ction and amyloid pathogenesis
@nl
prefLabel
Genetic dissection of the amyl ...... ction and amyloid pathogenesis
@ast
Genetic dissection of the amyl ...... ction and amyloid pathogenesis
@en
Genetic dissection of the amyl ...... ction and amyloid pathogenesis
@nl
P2093
P2860
P50
P3181
P356
P1476
Genetic dissection of the amyl ...... ction and amyloid pathogenesis
@en
P2093
Baiping Wang
Georgia Dolios
Katsuhiko Tabuchi
Robert E Hammer
Zilai Wang
P2860
P304
P3181
P356
10.1074/JBC.M110.137729
P407
P577
2010-10-01T00:00:00Z