Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.
about
The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foesAPP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functionsA new molecular explanation for age-related neurodegeneration: the Tyr682 residue of amyloid precursor proteinThe Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer's Disease NeuropathologyAn intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss.Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP-SorLA Interaction.APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation.NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease.An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients.Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary NeuronsBehavioural studies on the ethanol leaf extract of Grewia carpinifolia in Wistar rats.Not just amyloid: physiological functions of the amyloid precursor protein family.New Insights to Clathrin and Adaptor Protein 2 for the Design and Development of Therapeutic Strategies.Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and NeurodegenerationSortilin-Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer's Disease Patients Carrying the APOE Epsilon 4 Allele.Regulation of Neurotransmitter Release by Amyloid Precursor Protein Through Synapsin Phosphorylation.Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity.
P2860
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P2860
Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Tyr682 in the Aβ-precursor pro ...... on, and cognitive performance.
@ast
Tyr682 in the Aβ-precursor pro ...... on, and cognitive performance.
@en
type
label
Tyr682 in the Aβ-precursor pro ...... on, and cognitive performance.
@ast
Tyr682 in the Aβ-precursor pro ...... on, and cognitive performance.
@en
prefLabel
Tyr682 in the Aβ-precursor pro ...... on, and cognitive performance.
@ast
Tyr682 in the Aβ-precursor pro ...... on, and cognitive performance.
@en
P2093
P2860
P50
P356
P1433
P1476
Tyr682 in the Aβ-precursor pro ...... on, and cognitive performance.
@en
P2093
Alessia P M Barbagallo
Fabrizio Biundo
Franco Lombino
Martine Ammassari-Teule
Nadia Canu
Robert Tamayev
P2860
P304
P356
10.1111/ACEL.12009
P577
2012-10-12T00:00:00Z