Structure-based discovery of opioid analgesics with reduced side effects.
about
Drug discovery: Designing the ideal opioid"Solvent hydrogen-bond occlusion": A new model of polar desolvation for biomolecular energetics.Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the EndorphinsUnique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120.Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid ReceptorA review of perioperative anesthesia and analgesia for infants: updates and trends to watch.Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease.Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.4-isopropylcyclohexanol has potential analgesic effects through the inhibition of anoctamin 1, TRPV1 and TRPA1 channel activities.Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor.Signaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptors.Drug Binding Poses Relate Structure with Efficacy in the μ Opioid Receptor.The dynamic interaction between pain and opioid misuse.Discovery and Characterization of Novel GPR39 Agonists Allosterically Modulated by Zinc.Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain.A "tail" of opioid receptor variants.Insights into the function of opioid receptors from molecular dynamics simulations of available crystal structures.Analgesia: Screening for cleaner pain relief.Arresting the Development of Addiction: The Role of β-Arrestin 2 in Drug Abuse.Targeting multiple opioid receptors - improved analgesics with reduced side effects?Allostery at opioid receptors: modulation with small molecule ligands.Breaking barriers to novel analgesic drug development.Hurdles in Basic Science TranslationMolecular Docking, Molecular Dynamics, and Structure-Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists.Dynamic and Kinetic Elements of µ-Opioid Receptor Functional Selectivity.Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide.A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors.Cannabinoid CB1 and CB2 Receptor Signaling and BiasPoorly controlled postoperative pain: prevalence, consequences, and prevention.Computational design of environmental sensors for the potent opioid fentanyl.Insights into the Role of Opioid Receptors in the GI Tract: Experimental Evidence and Therapeutic Relevance.Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics.Designing Safer Analgesics via μ-Opioid Receptor Pathways.How Ligands Illuminate GPCR Molecular Pharmacology.How Oliceridine (TRV-130) Binds and Stabilizes a μ-Opioid Receptor Conformational State That Selectively Triggers G Protein Signaling Pathways.Identification of novel hits as highly prospective dual agonists for mu and kappa opioid receptors: an integrated in silico approach.Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents.Sequence-Specific Regulation of Endocytic Lifetimes Modulates Arrestin-Mediated Signaling at the µ Opioid Receptor.Modulation of opioid receptor affinity and efficacy via N-substitution of 9β-hydroxy-5-(3-hydroxyphenyl)morphan: Synthesis and computer simulation study.Computational insights into the subtype selectivity and "message-address-efficacy" mechanisms of opioid receptors through JDTic binding and unbinding.
P2860
Q26309894-D3AD2BDB-54EA-4F53-8C58-D964EE2274A7Q30400111-AE4ECAAB-CB7C-4A04-B629-7D6A17BB5A9EQ30841944-6F2EE76C-EB96-4059-9F55-8F2A03246B41Q30850022-61BA9635-418F-45BF-81FC-5A41A672CC9DQ33860286-FDF3C185-FBF6-48B9-8D3C-ED3065EB777BQ34552020-062B5F85-7779-477F-9F80-50CE4312438BQ37553341-C9936E37-1C8F-4E2A-B9E6-61413461768BQ37629809-785F9880-8762-451B-A026-9213593FD21CQ37657758-5005822D-BA5D-4B11-8440-5797B5AF9797Q38429628-96D6DBBB-3F02-47B5-A8A3-6CC6DD250107Q38675922-F7A03647-5F1B-4A8C-A0B6-831C648ADA66Q38703573-44E86BA4-EF00-4215-B28B-EBB911A936BFQ38731968-44530B15-5F56-4D8E-8CA3-BBBAF3C188FFQ38734266-8B66294B-6CF9-449C-8FA6-CE333ABC23BAQ39157737-2CEEF7F2-1CCA-43FB-B0F6-B93D2FFEFD06Q39158190-A9A3F9E6-0253-40C2-8711-5C588CD80B22Q39165104-10AA7874-5E9D-414B-93E2-C9215755B5E5Q39166766-D9AF559F-E574-4EFD-AECA-E32961A048D3Q39182855-82DD52EA-AB09-4FA4-BE83-A7E26D604EB7Q39221109-6EA77AB3-2D72-4289-8412-F26FC6EABFC2Q39248479-716ABD67-B28C-438A-98ED-563ED8084A6CQ39360773-BDB1687A-9499-4C72-BE37-54DE698EB4D1Q41037577-DA3F6E05-3ECD-4D94-B18B-093ADA15EA92Q41061564-939B78BF-DDA2-4A43-8765-6C6BF4A85F92Q41200379-70CCE38F-DA29-4256-86C5-DABA4344DA35Q41605692-160B7E0A-AF37-45E1-8EFA-605EA85EF4BBQ41902757-06CA4EDB-A797-4655-8240-A24872CA8587Q42082356-83739845-A4FE-42A1-978E-06F698E045BCQ42283211-5BA310FC-BE5E-46A5-8565-A01128AD1ED4Q42635967-3F42C747-05FA-411C-B0E7-8A93610A4B59Q43062074-17901D85-D75C-49C6-9AD0-6CAE847A5CDAQ43075742-C5294FE3-16C1-431A-8847-16BA004D226AQ43075987-93F54471-93C0-404F-88CF-C3BA1BB842D1Q43757698-4B3503F8-4820-47A3-87D3-5015A2539724Q44340976-38499C29-9CEB-468D-928B-187C57B5EC5DQ44342538-E4E63B4F-4D85-4CC6-9FFA-C69351D774ADQ44343009-DE1F5265-9F5C-4B4D-A6D1-1EE6CB5D5B98Q44343075-950AA7C7-2E9D-4C30-978A-6A221CABE534Q44344079-7ACB7EF8-D3C0-41B1-977F-8F27751A0C53Q44349926-C34E4A4A-2F8B-498A-9BB2-CD34E13B226D
P2860
Structure-based discovery of opioid analgesics with reduced side effects.
description
2016 nî lūn-bûn
@nan
2016 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Structure-based discovery of opioid analgesics with reduced side effects
@nl
Structure-based discovery of opioid analgesics with reduced side effects.
@ast
Structure-based discovery of opioid analgesics with reduced side effects.
@en
type
label
Structure-based discovery of opioid analgesics with reduced side effects
@nl
Structure-based discovery of opioid analgesics with reduced side effects.
@ast
Structure-based discovery of opioid analgesics with reduced side effects.
@en
prefLabel
Structure-based discovery of opioid analgesics with reduced side effects
@nl
Structure-based discovery of opioid analgesics with reduced side effects.
@ast
Structure-based discovery of opioid analgesics with reduced side effects.
@en
P2093
P2860
P50
P3181
P356
P1433
P1476
Structure-based discovery of opioid analgesics with reduced side effects.
@en
P2093
Anat Levit
Brian K Shoichet
Bryan L Roth
Daniela Dengler
Dipendra K Aryal
Gregory Corder
Harald Hübner
John D McCorvy
P2860
P2888
P304
P3181
P356
10.1038/NATURE19112
P407
P577
2016-08-17T00:00:00Z
P6179
1003034403