Multi-Facial, Non-Peptidic α-Helix Mimetics

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Structural Re-engineering of the α-Helix Mimetic JY-1-106 into Small Molecules: Disruption of the Mcl-1-Bak-BH3 Protein-Protein Interaction with 2,6-Di-Substituted Nicotinates

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Q36818334-B78A75CB-6AAE-4884-B824-2F16098841D1

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Multi-Facial, Non-Peptidic α-Helix Mimetics

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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Multi-Facial, Non-Peptidic α-Helix Mimetics

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Multi-Facial, Non-Peptidic α-Helix Mimetics

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Multi-Facial, Non-Peptidic α-Helix Mimetics

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Multi-Facial, Non-Peptidic α-Helix Mimetics

@ast

Multi-Facial, Non-Peptidic α-Helix Mimetics

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Multi-Facial, Non-Peptidic α-Helix Mimetics

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Multi-Facial, Non-Peptidic α-Helix Mimetics

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Multi-Facial, Non-Peptidic α-Helix Mimetics

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Multi-Facial, Non-Peptidic α-Helix Mimetics

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P1476

Multi-Facial, Non-Peptidic α-Helix Mimetics

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P2093

Maryanna E Lanning

http://www.w3.org/2001/XMLSchema#string

Steven Fletcher

http://www.w3.org/2001/XMLSchema#string

P2860

The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity

Enhancement of α-Helix Mimicry by an α/β-Peptide Foldamer via Incorporation of a Dense Ionic Side-Chain Array

Anatomy of hot spots in protein interfaces

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

Substituted 1,4-benzodiazepine-2,5-diones as alpha-helix mimetic antagonists of the HDM2-p53 protein-protein interaction.

Solid-phase synthesis of an A-B loop mimetic of the Cepsilon3 domain of human IgE: macrocyclization by Sonogashira coupling.

Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.

Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics.

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540-55

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scholarly article

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10.3390/BIOLOGY4030540

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English

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http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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2015-01-01T00:00:00Z

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282277870

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P698

26404384

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P932

4588149

http://www.w3.org/2001/XMLSchema#string

Multi-Facial, Non-Peptidic α-Helix Mimetics

about

P2860

P2860

Multi-Facial, Non-Peptidic α-Helix Mimetics

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P5875

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P577

P5875

P698

P932