Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad
about
Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate HydrolysisExploring the role of conformational heterogeneity in cis-autoproteolytic activation of ThnT.Convergent biosynthetic pathways to β-lactam antibioticsStructural Insights into an Oxalate-producing Serine Hydrolase with an Unusual Oxyanion Hole and Additional Lyase Activity.Structure- and context-based analysis of the GxGYxYP family reveals a new putative class of glycoside hydrolaseSmall and Random Peptides: An Unexplored Reservoir of Potentially Functional Primitive Organocatalysts. The Case of Seryl-Histidine.Handicap-Recover Evolution Leads to a Chemically Versatile, Nucleophile-Permissive Protease.Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator.Why Ser and not Thr brokers catalysis in the trypsin foldβ-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis.Ligand binding to the FA3-FA4 cleft inhibits the esterase-like activity of human serum albuminConvergent evolution of defensin sequence, structure and function.Acetaminophen interacts with human hemoglobin: optical, physical and molecular modeling studies.Using the MEROPS Database for Proteolytic Enzymes and Their Inhibitors and Substrates.Dynamical footprint of falcipain-2 catalytic triad in hemoglobin-β-bound state.Characterization of the deubiquitination activity and substrate specificity of the chicken ubiquitin-specific protease 1/USP associated factor 1 complex.The Defensins Consist of Two Independent, Convergent Protein Superfamilies.Biochemical characterization a digestive trypsin in the midgut of large cabbage white butterfly, Pieris brassicae L. (Lepidoptera: Pieridae).Discovery of Culex pipiens associated tunisia virus: a new ssRNA(+) virus representing a new insect associated virus family.Structural basis of ribosomal peptide macrocyclization in plants.Binding of ibuprofen to human hemoglobin: elucidation of their molecular recognition by spectroscopy, calorimetry, and molecular modeling techniques.Monobactam formation in sulfazecin by a nonribosomal peptide synthetase thioesterase.Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum.Divergent and convergent evolution of housekeeping genes in human-pig lineage.Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational EnsembleFunctional Properties of Amino Acid Side Chains as Biomarkers of Extraterrestrial LifeQM/MM Description of Newly Selected Catalytic Bioscavengers Against Organophosphorus Compounds Revealed Reactivation Stimulus Mediated by Histidine Residue in the Acyl-Binding Loop
P2860
Q27683557-4AB998DE-D2D0-4627-A904-F21EB5D01401Q27684351-4F38D6B5-8501-46C3-8D74-C58DA7B85E9FQ28071667-C02820F8-FEA9-4E41-95F5-81F711745551Q30388529-FEC97EA8-CC07-490D-A0A2-366539C68F87Q33809751-8734CC5E-8AA8-4120-B1D4-0C300A383607Q33856497-90197C6A-8E07-443F-B229-E45C2AE6551EQ34481684-0BD086E1-15F3-4975-AA21-E6C3D0C025C8Q34542669-EA276BEA-6E60-4C59-ABFA-0283D165B865Q35127936-A2868615-2B5E-4B28-9D4B-10FC276A3164Q35463323-78DA3D0A-6780-470A-94C8-EBEC4FE72B34Q35581476-B9F47FD0-4B30-4EDA-A136-9A4BE4FD6003Q38936327-7F43C0A8-D420-4262-93D1-8F1D9B7CDEBDQ39840141-E0287FFF-0926-4E0C-BC6B-E4B0BE696079Q41697054-C49036EB-F2F5-4C3C-A04E-845F16D81087Q42209923-67402838-5837-45B1-ADFD-D108022D25BCQ47160528-76ADD4A6-B683-4239-B458-5CDB582BD6F5Q47301333-56D9B8A5-1D0C-4A42-95B0-06C784CE5E59Q47432475-79FB6F26-AC76-4E40-ABF1-51DB67D7C7D7Q47552724-4AED4D36-7315-40B9-A4EB-9461CC5E91F4Q47694554-7191F0F1-16FA-48F0-B1BE-66923D9120BFQ47760068-118690DB-01C5-4B27-88FF-D3B7B552B9BBQ48272252-A7AA0B99-D203-4672-A7ED-FFE4885A621AQ55020721-703B2436-8D2D-4415-A896-7E44EC499400Q55313924-C8E2706D-45E6-489F-930B-7EE51FB7D92AQ56890015-EA425027-6BFD-45BA-A880-FB2EEB2F5897Q57091317-4565294F-BA64-47FB-AC58-B5D28B048666Q57558945-4EE3C156-FD60-4E12-94EB-C5431C889412
P2860
Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad
description
2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Intrinsic evolutionary constra ...... dentity of the catalytic triad
@ast
Intrinsic evolutionary constra ...... dentity of the catalytic triad
@en
Intrinsic evolutionary constra ...... dentity of the catalytic triad
@nl
type
label
Intrinsic evolutionary constra ...... dentity of the catalytic triad
@ast
Intrinsic evolutionary constra ...... dentity of the catalytic triad
@en
Intrinsic evolutionary constra ...... dentity of the catalytic triad
@nl
prefLabel
Intrinsic evolutionary constra ...... dentity of the catalytic triad
@ast
Intrinsic evolutionary constra ...... dentity of the catalytic triad
@en
Intrinsic evolutionary constra ...... dentity of the catalytic triad
@nl
P2860
P356
P1476
Intrinsic evolutionary constra ...... dentity of the catalytic triad
@en
P2093
Craig A Townsend
P2860
P304
P356
10.1073/PNAS.1221050110
P407
P577
2013-02-04T00:00:00Z