Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble

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Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble

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im Juni 2018 veröffentlichter wissenschaftlicher Artikel

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wetenschappelijk artikel

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наукова стаття, опублікована в червні 2018

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Directed Evolution Mimics Allo ...... of the Conformational Ensemble

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Directed Evolution Mimics Allo ...... of the Conformational Ensemble

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Directed Evolution Mimics Allo ...... of the Conformational Ensemble

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Directed Evolution Mimics Allo ...... of the Conformational Ensemble

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Directed Evolution Mimics Allo ...... of the Conformational Ensemble

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Directed Evolution Mimics Allo ...... of the Conformational Ensemble

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P1476

Directed Evolution Mimics Allo ...... of the Conformational Ensemble

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P2093

Jackson K B Cahn

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Michael Herger

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Paul van Roye

http://www.w3.org/2001/XMLSchema#string

Remkes A Scheele

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P2860

Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad

Structural and energetic basis of allostery

The ensemble nature of allostery

Crystal structure of the beta Ser178--> Pro mutant of tryptophan synthase. A "knock-out" allosteric enzyme

Allosteric regulation of substrate channeling in tryptophan synthase: modulation of the L-serine reaction in stage I of the beta-reaction by alpha-site ligands

Hidden alternative structures of proline isomerase essential for catalysis

Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase

X-ray and NMR crystallography in an enzyme active site: the indoline quinonoid intermediate in tryptophan synthase

Allostery and Substrate Channeling in the Tryptophan Synthase Bienzyme Complex: Evidence for Two Subunit Conformations and Four Quaternary States

Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR

P304

7256-7266

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P31

scholarly article

P356

10.1021/JACS.8B03490

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

140

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P50

Frances Arnold

Andrew R Buller

P577

2018-06-13T00:00:00Z

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P698

29712420

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P921

catalysis

general chemistry

P932

5999571

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