Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai
about
STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activationPOST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transportersSTIM1 couples to ORAI1 via an intramolecular transition into an extended conformationStore-independent activation of Orai1 by SPCA2 in mammary tumorsSTIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levelsAgonist-activated Ca2+ influx occurs at stable plasma membrane and endoplasmic reticulum junctionsA protease-independent function for SPPL3 in NFAT activationA novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cellsSTIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel componentsSTIM proteins: dynamic calcium signal transducersNew developments in mast cell biologyDual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and toleranceSTIM1 heteromultimerizes TRPC channels to determine their function as store-operated channelsAn EF hand mutation in Stim1 causes premature platelet activation and bleeding in miceStore-operated Ca2+ channels in airway epithelial cell function and implications for asthmaSTIM and ORAI proteins in the nervous systemStructural aspects of calcium-release activated calcium channel functionPhospholipase C signaling and calcium influxEmerging role of TRP channels in cell migration: from tumor vascularization to metastasisIon channels and transporters in lymphocyte function and immunityPermeation, selectivity and gating in store-operated CRAC channelsOrai3--the 'exceptional' Orai?The STIM1/Orai signaling machineryMolecular regulation of CRAC channels and their role in lymphocyte functionEmerging roles of L-type voltage-gated and other calcium channels in T lymphocytesStore-operated Orai channels: structure and functionMultifaceted roles of STIM proteinsStore-operated Ca2+ entry in muscle physiology and diseasesStore-independent modulation of Ca(2+) entry through Orai by Septin 7.Regulation of STIM1 and SOCE by the ubiquitin-proteasome system (UPS)The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathwayInterlinked dual-time feedback loops can enhance robustness to stochasticity and persistence of memoryAuto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entryCrystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+*Calmodulin Displays a Unique Binding ModeCrystal Structure of the Calcium Release-Activated Calcium Channel OraiMolecular mechanism of the assembly of an acid-sensing receptor ion channel complex.Diseases caused by mutations in ORAI1 and STIM1STIM1 gates TRPC channels, but not Orai1, by electrostatic interactionMapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation
P2860
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P2860
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai
description
2006 nî lūn-bûn
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2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Molecular identification of th ...... electivity in a mutant of Orai
@ast
Molecular identification of th ...... electivity in a mutant of Orai
@de
Molecular identification of th ...... electivity in a mutant of Orai
@en
Molecular identification of th ...... electivity in a mutant of Orai
@nl
type
label
Molecular identification of th ...... electivity in a mutant of Orai
@ast
Molecular identification of th ...... electivity in a mutant of Orai
@de
Molecular identification of th ...... electivity in a mutant of Orai
@en
Molecular identification of th ...... electivity in a mutant of Orai
@nl
prefLabel
Molecular identification of th ...... electivity in a mutant of Orai
@ast
Molecular identification of th ...... electivity in a mutant of Orai
@de
Molecular identification of th ...... electivity in a mutant of Orai
@en
Molecular identification of th ...... electivity in a mutant of Orai
@nl
P2860
P3181
P356
P1433
P1476
Molecular identification of th ...... electivity in a mutant of Orai
@en
P2860
P2888
P3181
P356
10.1038/NATURE05108
P407
P577
2006-08-20T00:00:00Z
P5875
P6179
1003808345