Common fragile sites: genomic hotspots of DNA damage and carcinogenesis - Wikidata - awgldk - TriplyDB

Common fragile sites: genomic hotspots of DNA damage and carcinogenesis

Common fragile sites: genomic hotspots of DNA damage and carcinogenesis

http://www.wikidata.org/entity/Q26825040

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Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?Rescue from replication stress during mitosis.A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women Canine urothelial carcinoma: genomically aberrant and comparatively relevant.Genomic instability in the PARK2 locus is associated with Parkinson's disease.Somatic Copy Number Alterations at Oncogenic Loci Show Diverse Correlations with Gene Expression.Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases First molecular-cytogenetic characterization of Fanconi anemia fragile sites in primary lymphocytes of FA-D2 patients in different stages of the disease.Polymorphisms of the homologous recombination gene RAD51 in keratoconus and Fuchs endothelial corneal dystrophy Alternative lengthening of telomeres: recurrent cytogenetic aberrations and chromosome stability under extreme telomere dysfunction.Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes.Cellular senescence: from growth arrest to immunogenic conversion.FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage.A high resolution map of mammalian X chromosome fragile regions assessed by large-scale comparative genomics.What is a Hotspot Anyway?Inhibition of colorectal cancer genomic copy number alterations and chromosomal fragile site tumor suppressor FHIT and WWOX deletions by DNA mismatch repair.Exceptional Chromosomal Evolution and Cryptic Speciation of Blind Mole Rats Nannospalax leucodon (Spalacinae, Rodentia) from South-Eastern Europe.The untold stories of the speech gene, the FOXP2 cancer gene.Complex chromosomal rearrangements leading toMECOMoverexpression are recurrent in myeloid malignancies with various 3q abnormalities

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P2860

Common fragile sites: genomic hotspots of DNA damage and carcinogenesis

http://www.wikidata.org/entity/Q26825040

description

2012 nî lūn-bûn

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2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Common fragile sites: genomic hotspots of DNA damage and carcinogenesis

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Common fragile sites: genomic hotspots of DNA damage and carcinogenesis

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Common fragile sites: genomic hotspots of DNA damage and carcinogenesis

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type

label

Common fragile sites: genomic hotspots of DNA damage and carcinogenesis

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Common fragile sites: genomic hotspots of DNA damage and carcinogenesis

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Common fragile sites: genomic hotspots of DNA damage and carcinogenesis

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Common fragile sites: genomic hotspots of DNA damage and carcinogenesis

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Common fragile sites: genomic hotspots of DNA damage and carcinogenesis

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Common fragile sites: genomic hotspots of DNA damage and carcinogenesis

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International Journal of Molecular Sciences

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Common fragile sites: genomic hotspots of DNA damage and carcinogenesis

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Jun Zhang

http://www.w3.org/2001/XMLSchema#string

Ke Ma

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Kristin Mrasek

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Li Qiu

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Luciana Gonçalves Quintana

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Thomas Liehr

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Zheng Li

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Creative Commons Attribution 3.0 Unported

P2860

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers

The tumor spectrum in FHIT-deficient mice

Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study

Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites

Molecular basis for expression of common and rare fragile sites

Targeted deletion of Wwox reveals a tumor suppressor function

WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome

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10.3390/IJMS130911974

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genetic variation

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