Molecular basis for expression of common and rare fragile sites - Wikidata - awgldk - TriplyDB

Molecular basis for expression of common and rare fragile sites

Molecular basis for expression of common and rare fragile sites

http://www.wikidata.org/entity/Q24653358

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Mechanisms of gene duplication and amplification Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer The replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplication Comparative genomics and molecular dynamics of DNA repeats in eukaryotes Common fragile sites: genomic hotspots of DNA damage and carcinogenesis Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving the DPYD enigma Endogenous florendoviruses are major components of plant genomes and hallmarks of virus evolution Gene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolution DNA fragile site breakage as a measure of chemical exposure and predictor of individual susceptibility to form oncogenic rearrangements.Environmental and chemotherapeutic agents induce breakage at genes involved in leukemia-causing gene rearrangements in human hematopoietic stem/progenitor cells.Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap Trios, and relation to fragile site location.DNA double-strand break repair and the evolution of intron density.Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites.DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment.DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells.Secondary structure formation and DNA instability at fragile site FRA16B CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity.Mechanisms of genomic instabilities underlying two common fragile-site-associated loci, PARK2 and DMD, in germ cell and cancer cell lines DNA instability at chromosomal fragile sites in cancer One in four individuals of African-American ancestry harbors a 5.5kb deletion at chromosome 11q13.1.Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites.Mammalian NUMT insertion is non-random Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer.DNA topoisomerases participate in fragility of the oncogene RET.Sporadic breast cancer patients' germline DNA exhibit an AT-rich microsatellite signature.Large transcription units unify copy number variants and common fragile sites arising under replication stress Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes.Tandem repeats and G-rich sequences are enriched at human CNV breakpoints Global mapping of DNA conformational flexibility on Saccharomyces cerevisiae.Is mammalian chromosomal evolution driven by regions of genome fragility?Intracellular signal transduction and modification of the tumor microenvironment induced by RET/PTCs in papillary thyroid carcinoma.A genome-wide analysis of common fragile sites: what features determine chromosomal instability in the human genome?The role of fragile sites in sporadic papillary thyroid carcinoma Replication stress induces tumor-like microdeletions in FHIT/FRA3B Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication.A TRF1-controlled common fragile site containing interstitial telomeric sequences.Role of DNA secondary structures in fragile site breakage along human chromosome 10

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P2860

Molecular basis for expression of common and rare fragile sites

http://www.wikidata.org/entity/Q24653358

description

2003 nî lūn-bûn

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2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Molecular basis for expression of common and rare fragile sites

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Molecular basis for expression of common and rare fragile sites

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Molecular basis for expression of common and rare fragile sites

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type

label

Molecular basis for expression of common and rare fragile sites

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Molecular basis for expression of common and rare fragile sites

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Molecular basis for expression of common and rare fragile sites

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prefLabel

Molecular basis for expression of common and rare fragile sites

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Molecular basis for expression of common and rare fragile sites

@en

Molecular basis for expression of common and rare fragile sites

@nl

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MCB.23.20.7143-7151.2003

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Molecular and Cellular Biology

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Molecular basis for expression of common and rare fragile sites

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Ayala Levi

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Ayelet Rahat

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Batsheva Kerem

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Efrat Ozeri

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Eitan Zlotorynski

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Jennifer Skaug

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Neta Ben-Porat

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Ruth Hershberg

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P2860

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit

Initiation of the breakage-fusion-bridge mechanism through common fragile site activation in human breast cancer cells: the model of PIP gene duplication from a break at FRA7I

The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1

DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes

FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites

Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2

Trinucleotide repeats that expand in human disease form hairpin structures in vitro

Human chromosomal fragile site FRA16B is an amplified AT-rich minisatellite repeat

ATR Regulates Fragile Site Stability

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7143-51

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1239777

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10.1128/MCB.23.20.7143-7151.2003

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20

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9074281

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