Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins - Wikidata - awgldk - TriplyDB

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

http://www.wikidata.org/entity/Q26991478

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Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat Cancer Genetic polymorphism in extracellular regulators of Wnt signaling pathway Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies Progress and renewal in gustation: new insights into taste bud development Crystal Structures of Lgr4 and Its Complex with R-Spondin1 Drugging a stem cell compartment using Wnt3a protein as a therapeutic On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells Crystal structure of LGR4-Rspo1 complex: insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs).Making sense of Wnt signaling-linking hair cell regeneration to development.The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors Expression and functional regulation of stemness gene Lgr5 in esophageal squamous cell carcinoma.Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning.The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.Distribution of slow-cycling cells in epiphyseal cartilage and requirement of β-catenin signaling for their maintenance in growth plate.Comparison of leucine-rich repeat-containing G protein-coupled receptor 5 expression in different cancer and normal cell lines.Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila.Synchrotron-based imaging of chromium and γ-H2AX immunostaining in the duodenum following repeated exposure to Cr(VI) in drinking water.Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury.Mesenchymal stem cell therapy stimulates endogenous host progenitor cells to improve colonic epithelial regeneration.Integrative ChIP-seq/microarray analysis identifies a CTNNB1 target signature enriched in intestinal stem cells and colon cancer Denervation suppresses gastric tumorigenesis.Distinct human stem cell populations in small and large intestine.LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal Cancer biology: a new RING to Wnt signaling.Identification of Wnt Pathway Target Genes Regulating the Division and Differentiation of Larval Seam Cells and Vulval Precursor Cells in Caenorhabditis elegans Runx1: no longer just for leukemia Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells Lrp5 Has a Wnt-Independent Role in Glucose Uptake and Growth for Mammary Epithelial Cells miR-215 promotes malignant progression of gastric cancer by targeting RUNX1 Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli.Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A.Knockdown of LGR5 suppresses the proliferation of glioma cells in vitro and in vivo.Leucine-rich repeat-containing G-protein coupled receptor 5/GPR49 activates G12/13-Rho GTPase pathway Establishing estrogen-responsive mouse mammary organoids from single Lgr5+ cells.BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes.Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus.Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer Overexpression of FZD7 promotes glioma cell proliferation by upregulating TAZ.

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Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

http://www.wikidata.org/entity/Q26991478

description

2012 nî lūn-bûn

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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2012 թվականի հունիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

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Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

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Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

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type

label

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

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Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

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Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

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Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

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Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

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Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

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The EMBO Journal

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Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

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P2860

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.

Association of the APC gene product with beta-catenin

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension

Coat variation in the domestic dog is governed by variants in three genes

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10.1038/EMBOJ.2012.149

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12

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Jurian Schuijers

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225056158

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3380219

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