R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling
about
Novel insights into the bovine polled phenotype and horn ontogenesis in BovidaeR-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5The spatial distribution of LGR5+ cells correlates with gastric cancer progressionTumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptorsZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive mannerConstitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi networkLGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressorInteraction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondinWnt/beta-catenin signaling and small molecule inhibitorsInternational Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligandsLGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signalingMammary Development and Breast Cancer: A Wnt PerspectiveControl of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in CancerFrizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat CancerIn a Class of Their Own - RXFP1 and RXFP2 are Unique Members of the LGR FamilyLGR4 and Its Role in Intestinal Protection and Energy MetabolismKeeping Wnt signalosome in check by vesicular trafficG Protein-Coupled Receptor Signaling in Stem Cells and CancerGenetic polymorphism in extracellular regulators of Wnt signaling pathwayAdult mammalian stem cells: the role of Wnt, Lgr5 and R-spondinsWnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia developmentDefining hierarchies of stemness in the intestine: evidence from biomarkers and regulatory pathwaysThe R-spondin protein familyCellular signaling and biological functions of R-spondinsA rapid and affordable screening platform for membrane protein trafficking.The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids.LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea.Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions.The structural basis of R-spondin recognition by LGR5 and RNF43Structural basis for R-spondin recognition by LGR4/5/6 receptorsCrystal Structures of Lgr4 and Its Complex with R-Spondin1Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondinStructures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for SignalingLong-term culture of genome-stable bipotent stem cells from adult human liverWNT signaling in bone homeostasis and disease: from human mutations to treatmentsUnlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axisG-protein coupled receptor expression patterns delineate medulloblastoma subgroupsColorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in cultureRecombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cellsR-spondins/Lgrs expression in tooth development
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P2860
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
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2011年學術文章
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name
R-spondins function as ligands ...... ate Wnt/beta-catenin signaling
@ast
R-spondins function as ligands ...... ate Wnt/beta-catenin signaling
@en
R-spondins function as ligands ...... ate Wnt/beta-catenin signaling
@en-gb
R-spondins function as ligands ...... ate Wnt/beta-catenin signaling
@nl
type
label
R-spondins function as ligands ...... ate Wnt/beta-catenin signaling
@ast
R-spondins function as ligands ...... ate Wnt/beta-catenin signaling
@en
R-spondins function as ligands ...... ate Wnt/beta-catenin signaling
@en-gb
R-spondins function as ligands ...... ate Wnt/beta-catenin signaling
@nl
prefLabel
R-spondins function as ligands ...... ate Wnt/beta-catenin signaling
@ast
R-spondins function as ligands ...... ate Wnt/beta-catenin signaling
@en
R-spondins function as ligands ...... ate Wnt/beta-catenin signaling
@en-gb
R-spondins function as ligands ...... ate Wnt/beta-catenin signaling
@nl
P2093
P2860
P921
P3181
P356
P1476
R-spondins function as ligands ...... ate Wnt/beta-catenin signaling
@en
P2093
Anthony Thomas
Qingyun Liu
Qiushi Lin
P2860
P304
11452-11457
P3181
P356
10.1073/PNAS.1106083108
P407
P577
2011-06-21T00:00:00Z