Targeting Mcl-1 for the therapy of cancer - Wikidata - awgldk - TriplyDB

Targeting Mcl-1 for the therapy of cancer

Targeting Mcl-1 for the therapy of cancer

http://www.wikidata.org/entity/Q27011870

about

Targeting the Bcl-2 family for cancer therapy The mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death Stapled BH3 peptides against MCL-1: mechanism and design using atomistic simulations Mitochondrial apoptosis and BH3 mimetics Alternative Treatments For Melanoma: Targeting BCL-2 Family Members to De-Bulk and Kill Cancer Stem Cells Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells.Estrogen regulation of anti-apoptotic Bcl-2 family member Mcl-1 expression in breast cancer cells Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells Regulation of HPV16 E6 and MCL1 by SF3B1 inhibitor in head and neck cancer cells.Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells OSU-03012 interacts with lapatinib to kill brain cancer cells Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73.Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo.Overexpression of Mcl-1L splice variant is associated with poor prognosis and chemoresistance in oral cancers.The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737 Silence of MCL-1 upstream signaling by shRNA abrogates multiple myeloma growth.Myeloid cell leukemia-1 is associated with tumor progression by inhibiting apoptosis and enhancing angiogenesis in colorectal cancer.Triptolide induces apoptotic cell death of human cholangiocarcinoma cells through inhibition of myeloid cell leukemia-1.Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline.Mitochondrial Ion Channels in Cancer Transformation Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy.miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer.Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1 Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation Mcl-1 is an important therapeutic target for oral squamous cell carcinomas.ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer.Broad targeting of resistance to apoptosis in cancer.Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1/2 inhibitors in melanoma.pRb/E2F-1-mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2/Bcl-xL inhibitor ABT-737 Protein Kinase Inhibitor H89 Enhances the Activity of Pseudomonas Exotoxin A-Based Immunotoxins.MUC1-C Stabilizes MCL-1 in the Oxidative Stress Response of Triple-Negative Breast Cancer Cells to BCL-2 Inhibitors.Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells.MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib.Dual modulation of MCL-1 and mTOR determines the response to sunitinib.Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis

P2860

Q26866936-6410FF23-BFB3-41B1-8ED6-919C1B6663CB Q27012559-81940123-50E2-4AA8-8D3C-47E2F51BAE3C Q27321588-C73A69B7-FC48-4B33-AD0C-50729CA1187A Q28069552-AC0CD8F6-63EB-452A-BC0A-D58742C77C31 Q28084243-AD4D73E2-1170-42DC-923D-F9F55F6A300C Q28534817-CAD12656-B58D-4A8B-BEB5-9EBD8B27682F Q30300019-2462A515-18D9-4485-879E-58E08E8AC1BC Q33612421-FA77DF44-32D3-4A3E-8E4C-D3B01C2B1515 Q33817324-3667EEB3-26C9-4370-A805-64CB993C3F4F Q33851111-F6D4C28B-AAF3-4C39-95C2-F953C7CF33DC Q34007721-AC3758AA-176B-480F-A5CF-934D21D573EF Q34068144-E15CD652-805A-40D0-B7BE-53199E8C19BE Q34070349-4AA985A5-E5AD-44A9-A360-E8FEADD92884 Q34227586-8E30CD1A-80DC-4AFE-9496-101F26898ECD Q34300517-DD1AF40F-420C-451C-8546-F4B1C856F37A Q34365839-F80F3F56-C5E7-4508-B24A-8EFC713C37AD Q34406244-8E287BA8-60CF-47DA-818F-89FCAC5A7C04 Q34541989-CF113814-B6F2-467D-9F9A-40ED0DCDD570 Q34557856-79EE3F5A-F053-4782-B883-4364A556F8E6 Q34566043-C851999C-8D01-47A1-9D29-EDE3653C0E68 Q34991284-B0052A67-82C4-4155-A2EF-3983D53DA93D Q35151115-9B6E31CA-E03B-4E02-9E41-13123CF9E1E7 Q35676278-1F100EE2-51F4-491A-8AE7-8D9679E376FE Q35682293-2AD87313-A717-4235-9EEA-78064CC7CE1E Q35742477-572027C6-8DE5-4ACD-831D-D27F3CBB7CC6 Q35794952-5A83A9AA-30BD-49DB-A141-132B39A6CE32 Q35876252-0DA27310-1B37-4702-AF9C-91574BA72064 Q35880102-2CD39BE2-4C97-41B7-BB59-7594A996DE37 Q36140893-A59B83E8-AB0C-4FFF-B58B-41E84907C252 Q36413318-9E56FC98-97F8-4789-A2C9-FCB86767825E Q36483749-AB554AD0-33B4-42E7-B047-74C57D1D17DC Q36562077-6C7AFA43-EF10-4444-8611-0FDC0134583B Q36747304-AA8AACCB-04D7-40E0-89D4-6AC41B04838D Q36917916-37A6842B-AEE7-4037-B444-9DC2AF6544C3 Q36928457-6F47937B-86AD-41E6-94D0-4CE0EF6D89FE Q37149641-616C4A51-91A0-40BF-9BCE-1044105CDBD2 Q37384594-ABE988D7-3424-4D77-B434-5B906D740E06 Q37487789-34E5D74F-A650-43C7-B3F1-7FAC241D5475 Q37544978-5B33D308-FC0F-45EA-AF18-765F34159C06 Q37610475-93FCDBC1-F968-45BA-AEEB-79F7BDDA92D7

P2860

Targeting Mcl-1 for the therapy of cancer

http://www.wikidata.org/entity/Q27011870

description

2011 nî lūn-bûn

@nan

2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年学术文章

@wuu

2011年学术文章

@zh-cn

2011年学术文章

@zh-hans

2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

name

Targeting Mcl-1 for the therapy of cancer

@ast

Targeting Mcl-1 for the therapy of cancer

@en

Targeting Mcl-1 for the therapy of cancer

@nl

type

label

Targeting Mcl-1 for the therapy of cancer

@ast

Targeting Mcl-1 for the therapy of cancer

@en

Targeting Mcl-1 for the therapy of cancer

@nl

prefLabel

Targeting Mcl-1 for the therapy of cancer

@ast

Targeting Mcl-1 for the therapy of cancer

@en

Targeting Mcl-1 for the therapy of cancer

@nl

P1433

Q27011870-60F52BF6-C37D-4B68-B813-519012B9D022

P1476

Q27011870-C5263780-C08C-4F77-B8D0-6C5F50C89DCF

P2093

Q27011870-15F9063E-5D23-4F6C-921D-338566C34551

Q27011870-277D9C39-3C58-47ED-ADC9-DD434452E166

Q27011870-45304E7B-6A14-483E-98F7-CC800900B28E

Q27011870-4E120D07-CB24-4541-81E0-1DEF9FA8AB67

Q27011870-4EBFA8B4-E625-43A7-BA75-FABFAA4A52E8

Q27011870-55B5A5BB-EFF8-4BC2-B2D3-791407F137A9

Q27011870-58081D10-A0C0-45F9-BDC4-6575A0F884DB

Q27011870-7AF1ADF0-60A1-457C-90EB-503DF0CDF05C

Q27011870-8F824C2F-F625-4258-9260-1550613F0F45

Q27011870-96BAB6DB-026A-4439-ACF0-FB932C20FF07

P2860

Q27011870-05669E29-4E04-4BBE-A6B5-B675EF0B4370

Q27011870-08A20AE9-E128-40F1-AFCD-331170B997A9

Q27011870-094BB28E-52AC-4691-A4D3-46EAD884F4F8

Q27011870-0A4D0D76-819F-41C6-8FA2-B2548FE594A4

Q27011870-0F5B4DE0-9B9B-4872-B89C-1D48DB1B1327

Q27011870-11F4DAA5-EBF6-4FCD-9098-BC526B55134F

Q27011870-1404D297-5F63-4EB4-B744-0ECEE2A9ADE6

Q27011870-164F10E3-B1A6-4E0D-BBA9-53C75813A7E0

Q27011870-1660CB01-7DC4-464A-B2AA-F7EB088E5F3A

Q27011870-19A3DDF3-06A7-4C1F-8D0F-20EF87E30839

P304

Q27011870-37C0A879-6749-406E-8465-8A382203D731

P31

Q27011870-0EFF05DC-3E5B-40D7-8A7E-BEAEDFF336E2

P3181

Q27011870-3C851E03-F6DD-44F3-8100-4B7210FD0A6A

P356

Q27011870-EBCE2DA3-0D49-49AE-9EAF-3911AAA207CE

P407

Q27011870-69B79F9A-2D49-4537-92AD-E18CF0CA066D

P433

Q27011870-9D4F3684-F89B-4B9D-BD9D-733A2415569B

P478

Q27011870-7E13ED68-9E46-40B9-956E-306F948C2163

P50

Q27011870-1F52AB68-C87B-416E-9847-BC1C51B2D317

Q27011870-31CF813E-78FE-4A6B-9A19-2D7A03AB7A49

Q27011870-3EA3B40D-E56B-483E-AF7A-FAF2DB9BF3B2

Q27011870-89C1644A-D1E9-4510-865E-3D7D84D82E96

P577

Q27011870-B29F8CA9-C4A7-4B24-B1C9-83EEC60F3140

P5875

Q27011870-B258BD2B-542C-4077-9E9E-4C75D97C89BF

P698

Q27011870-EE16D286-F6C7-4318-B7B3-DF54D0C1F4DA

P932

Q27011870-EB278D6A-5933-423C-BED7-CCC43EAFA50A

P3181

P356

13543784.2011.609167

P1433

Expert Opinion on Investigational Drugs

P1476

Targeting Mcl-1 for the therapy of cancer

@en

P2093

Bainan Wu

http://www.w3.org/2001/XMLSchema#string

Belal Azab

http://www.w3.org/2001/XMLSchema#string

Bridget A Quinn

http://www.w3.org/2001/XMLSchema#string

Devanand Sarkar

http://www.w3.org/2001/XMLSchema#string

Igor Dmitriev

http://www.w3.org/2001/XMLSchema#string

John C Reed

http://www.w3.org/2001/XMLSchema#string

John L Stebbins

http://www.w3.org/2001/XMLSchema#string

Jun Wei

http://www.w3.org/2001/XMLSchema#string

Michael Hedvat

http://www.w3.org/2001/XMLSchema#string

Mohamed Rahmani

http://www.w3.org/2001/XMLSchema#string

P2860

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

mir-29 regulates Mcl-1 protein expression and apoptosis

Developing an effective gene therapy for prostate cancer: New technologies with potential to translate from the laboratory into the clinic

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

P304

1397-411

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1409063

http://www.w3.org/2001/XMLSchema#string

P356

10.1517/13543784.2011.609167

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

20

http://www.w3.org/2001/XMLSchema#string

P50

Maurizio Pellecchia

David T. Curiel

P577

2011-10-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51580427

http://www.w3.org/2001/XMLSchema#string

P698

21851287

http://www.w3.org/2001/XMLSchema#string

P932

3205956

http://www.w3.org/2001/XMLSchema#string