Nuclear export of proteins and drug resistance in cancer
about
Mechanisms of Nuclear Export in Cancer and Resistance to ChemotherapyPotential targets for ovarian clear cell carcinoma: a review of updates and future perspectivesStructural Basis of Targeting the Exportin CRM1 in CancerMultiple Export Mechanisms for mRNAsNuclear transport of galectin-3 and its therapeutic implicationsThe BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular LocationsTargeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal TransitionAntileukemic activity of nuclear export inhibitors that spare normal hematopoietic cellsSelective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemiaNext-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignanciesNAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathwayA Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the NucleusGenomic and molecular characterization of esophageal squamous cell carcinomaVerdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo.Longitudinal tracking of single live cancer cells to understand cell cycle effects of the nuclear export inhibitor, selinexor.First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid TumorsSelinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma.KPT-330 has antitumour activity against non-small cell lung cancer.Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma.Atomic basis of CRM1-cargo recognition, release and inhibitionNuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancerProtein mislocalization: mechanisms, functions and clinical applications in cancer.KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinoma.Nuclear export mediated regulation of microRNAs: potential target for drug intervention.Targeting nucleocytoplasmic transport in cancer therapyInhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agentsPreclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I study.Antitumor effects of a novel chromosome region maintenance 1 (CRM1) inhibitor on non-small cell lung cancer cells in vitro and in mouse tumor xenografts.shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance.Biologic activity of the novel orally bioavailable selective inhibitor of nuclear export (SINE) KPT-335 against canine melanoma cell lines.NESmapper: accurate prediction of leucine-rich nuclear export signals using activity-based profiles.LocNES: a computational tool for locating classical NESs in CRM1 cargo proteins.XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A.The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compoundsKPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin [corrected] in prostate cancer models.Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein.Selective Nuclear Export Inhibitor KPT-330 Enhances the Antitumor Activity of Gemcitabine in Human Pancreatic CancerRouting of Biomolecules and Transgenes' Vectors in Nuclei of OocytesThe E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation.
P2860
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P2860
Nuclear export of proteins and drug resistance in cancer
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Nuclear export of proteins and drug resistance in cancer
@ast
Nuclear export of proteins and drug resistance in cancer
@en
Nuclear export of proteins and drug resistance in cancer
@nl
type
label
Nuclear export of proteins and drug resistance in cancer
@ast
Nuclear export of proteins and drug resistance in cancer
@en
Nuclear export of proteins and drug resistance in cancer
@nl
prefLabel
Nuclear export of proteins and drug resistance in cancer
@ast
Nuclear export of proteins and drug resistance in cancer
@en
Nuclear export of proteins and drug resistance in cancer
@nl
P2093
P2860
P3181
P1476
Nuclear export of proteins and drug resistance in cancer
@en
P2093
Daniel M. Sullivan
Jana Dawson
Joel G. Turner
P2860
P304
P3181
P356
10.1016/J.BCP.2011.12.016
P407
P577
2012-04-15T00:00:00Z