about
Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cellsCardiotoxin III Inhibits Hepatocyte Growth Factor-Induced Epithelial-Mesenchymal Transition and Suppresses Invasion of MDA-MB-231 Cells.MET inhibitor PHA-665752 suppresses the hepatocyte growth factor-induced cell proliferation and radioresistance in nasopharyngeal carcinoma cells.Celastrol exerts synergistic effects with PHA-665752 and inhibits tumor growth of c-Met-deficient hepatocellular carcinoma in vivo.MET inhibition in tumor cells by PHA665752 impairs homologous recombination repair of DNA double strand breaks.A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras.Small molecule c-MET inhibitor PHA665752: effect on cell growth and motility in papillary thyroid carcinoma.A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts.Molecular predictors of sensitivity to the MET inhibitor PHA665752 in lung carcinoma cells.A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin.
P921
Q24541450-AE1F8080-877E-4C49-AC83-C488158C77E5Q30917936-CBC6249D-6582-41A7-95CD-AC44F0248CB8Q38843388-DE59DEB6-44E2-42C8-B036-F4482F619C9CQ38997809-E529871D-4CA0-4B8C-A847-8931BFAF24B1Q39155406-FBA4A07F-3D17-4C91-8B58-0DCDFB913C5DQ39576714-D395E750-EE99-4D05-A283-0373020C1FE0Q39991720-F2F894A4-CAF6-4A48-8B06-DB93424A807AQ40004623-6620E49D-5F85-42DE-B294-0DFF36285055Q40144642-1C9DA9E9-8183-49AE-8656-A026D55BC48DQ42926986-18536FCE-04EC-4A2D-9315-99B6F42775ADQ46402569-88486AD3-EEEA-4E0D-AC6A-876056AA31C0
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
pha-665752
@en
type
label
pha-665752
@en
altLabel
PHA 665752
@en
PHA665752
@en
TCMDC-125885
@en
prefLabel
pha-665752
@en
P592
P661
P662
P683
P1579
P2017
CC1=C(NC(=C1C(=O)N2CCC[C@@H]2C ...... O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O
P2067
640.167782
P231
477575-56-7
P233
CC1=C(NC(=C1C(=O)N2CCCC2CN3CCCC3)C)C=C4C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O
P234
1S/C32H34Cl2N4O4S/c1-19-29(35- ...... 3,(H,36,39)/b24-16-/t21-/m1/s1
P235
OYONTEXKYJZFHA-SSHUPFPWSA-N
P274
C₃₂H₃₄Cl₂N₄O₄S
P3117
DTXSID30197270
P592
CHEMBL450786
P652
0VXU5T5R3J