Shifting from the single to the multitarget paradigm in drug discovery - Wikidata - awgldk - TriplyDB

Shifting from the single to the multitarget paradigm in drug discovery

Shifting from the single to the multitarget paradigm in drug discovery

http://www.wikidata.org/entity/Q27144242

about

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion Systems psychopharmacology: A network approach to developing novel therapies Constellation pharmacology: a new paradigm for drug discovery Creation of a free, Internet-accessible database: the Multiple Target Ligand Database Quantitative modeling of dose–response and drug combination based on pathway network Targeting vascular endothelial growth factor receptor 2 and protein kinase D1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro Resistance-resistant antibiotics From single target to multitarget/network therapeutics in Alzheimer's therapy Computational chemogenomics: is it more than inductive transfer?Structural bioinformatics of the interactome.Nicotinic ligands as multifunctional agents for the treatment of neuropsychiatric disorders Rapid scanning structure-activity relationships in combinatorial data sets: identification of activity switches.Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity?Progress in the analysis of multiple activity profile of screening data using computational approaches.Updates on drug-target network; facilitating polypharmacology and data integration by growth of DrugBank database.Integrative analysis for identifying joint modular patterns of gene-expression and drug-response data.Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases.Potential strategies for increasing drug-discovery productivity.AlzhCPI: A knowledge base for predicting chemical-protein interactions towards Alzheimer's disease.Composition and applications of focus libraries to phenotypic assays Balancing novelty with confined chemical space in modern drug discovery.Libraries from Libraries: A Series of Sulfonamide Linked Heterocycles Derived from the Same Scaffold.New approaches to treating Alzheimer's disease Survival of patients with stage IV lung cancer with diabetes treated with metformin.Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts.2D and 3D similarity landscape analysis identifies PARP as a novel off-target for the drug Vatalanib.A cell-based screening assay to identify pharmaceutical compounds that enhance the regenerative quality of corneal repair.One size does not fit all: Challenging some dogmas and taboos in drug discovery.Effective Design of Multifunctional Peptides by Combining Compatible Functions DrugGenEx-Net: a novel computational platform for systems pharmacology and gene expression-based drug repurposing.A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT.Efficacy-oriented compatibility for component-based Chinese medicine Studies on [5,6]-Fused Bicyclic Scaffolds Derivatives as Potent Dual B-RafV600E/KDR Inhibitors Using Docking and 3D-QSAR Approaches.Anti-inflammatory effects of dabrafenib in vitro and in vivo.The scoring bias in reverse docking and the score normalization strategy to improve success rate of target fishing.Effects of the nicotinic agonist varenicline on the performance of tasks of cognition in aged and middle-aged rhesus and pigtail monkeys Modeling Fetal Alcohol Spectrum Disorder: Validating an Ex Vivo Primary Hippocampal Cell Culture System.Bakuchiol suppresses proliferation of skin cancer cells by directly targeting Hck, Blk, and p38 MAP kinase Targeting Anti-Cancer Active Compounds: Affinity-Based Chromatographic Assays.Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis

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P2860

Shifting from the single to the multitarget paradigm in drug discovery

http://www.wikidata.org/entity/Q27144242

description

2013 nî lūn-bûn

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2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2013 թվականի մայիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Shifting from the single to the multitarget paradigm in drug discovery

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Shifting from the single to the multitarget paradigm in drug discovery

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Shifting from the single to the multitarget paradigm in drug discovery

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type

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Shifting from the single to the multitarget paradigm in drug discovery

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Shifting from the single to the multitarget paradigm in drug discovery

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Shifting from the single to the multitarget paradigm in drug discovery

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Shifting from the single to the multitarget paradigm in drug discovery

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Shifting from the single to the multitarget paradigm in drug discovery

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Shifting from the single to the multitarget paradigm in drug discovery

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J.DRUDIS.2013.01.008

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Drug Discovery Today

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Shifting from the single to the multitarget paradigm in drug discovery

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Gregory S Welmaker

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José L Medina-Franco

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Marc A Giulianotti

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Richard A Houghten

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P2860

Chemoinformatic analysis of GRAS (Generally Recognized as Safe) flavor chemicals and natural products

Structure-based virtual screening for drug discovery: a problem-centric review

Open PHACTS: semantic interoperability for drug discovery

ZINC--a free database of commercially available compounds for virtual screening

Structural biology and drug discovery

Network pharmacology: the next paradigm in drug discovery

TCM Database@Taiwan: the world's largest traditional Chinese medicine database for drug screening in silico

Open access high throughput drug discovery in the public domain: a Mount Everest in the making.

Public domain databases for medicinal chemistry

Drug repositioning: identifying and developing new uses for existing drugs

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