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Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle PathwayMycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases.Characterization of the receptors for mycobacterial cord factor in Guinea pig.Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome.A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis.Recognition of the mycobacterial cord factor by Mincle: relevance for granuloma formation and resistance to tuberculosis.Development of a benzophenone and alkyne functionalised trehalose probe to study trehalose dimycolate binding proteins.Differential control of Mincle-dependent cord factor recognition and macrophage responses by the transcription factors C/EBPβ and HIF1α.Defining the conformation of human mincle that interacts with mycobacterial trehalose dimycolate.Cord factor (trehalose 6,6'-dimycolate) forms fully stable and non-permeable lipid bilayers required for a functional outer membrane.The mycobacterial cord factor adjuvant analogue trehalose-6,6'-dibehenate (TDB) activates the Nlrp3 inflammasome.Participation of tumor necrosis factor in the antitumor activity of mycobacterial trehalose dimycolate (cord factor)
P921
Q21131402-9B6F17CF-D9C2-4841-BFD5-568906377DC2Q34319337-BFE0F76A-FB73-4A4C-8F54-4E37BB15862DQ35095562-E9BB9C3C-0725-45E7-969A-88AE37D5C64AQ37037287-6BA0FF55-6E12-4966-BF57-F7FE9F03A872Q37682690-F1D80DD7-BBBF-4089-B4EA-73AB8455F161Q38077188-DF692EB7-0EF9-44F8-B69B-C68407325A7EQ39499759-88EAFD68-B6C4-43E2-A940-A5FD001F56D0Q42464512-FB0D2C17-50E2-4567-B4E7-25E7A726B619Q42964961-75B62611-A7A6-4821-9E87-38A326976777Q51019826-1079B659-63B7-43B1-887A-26BF8453FAEBQ54488375-194E7ABC-7693-404B-93BF-27B11F154DF7Q69775769-E3F403A1-6B87-4C78-9AD3-85E727B1DCBA
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
trehalose 6,6'-dimycolate
@en
type
label
trehalose 6,6'-dimycolate
@en
altLabel
AC1L9PSR
@en
alpha,alpha'-trehalose 6,6'-dimycolate
@en
cord factor
@en
mycobacterial trehalose dimycolate
@en
trehalose dimycolate
@en
prefLabel
trehalose 6,6'-dimycolate
@en
P661
P662
P683
P2017
CCCCCCCCCCCCCCCCCCCCCCCCCC(C(C ...... CCCCCCCCCCCCCC)O)O)O)O)O)O)O)O
P2067
2,052.883332
P233
CCCCCCCCCCCCCCCCCCCCCCCCCC(C(C ...... CCCCCCCCCCCCCC)O)O)O)O)O)O)O)O
P235
XETCRXVKJHBPMK-MJSODCSWSA-N
P274
C₁₃₀H₂₅₀O₁₅