Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
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Infectivity versus Seeding in Neurodegenerative Diseases Sharing a Prion-Like MechanismThe prion hypothesis in Parkinson's disease: Braak to the futureΑlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's DiseaseDisease-modifying therapeutic directions for Lewy-Body dementiasThe complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's diseaseFeatures of alpha-synuclein that could explain the progression and irreversibility of Parkinson's diseasePrion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic targetHuman-to-mouse prion-like propagation of mutant huntingtin protein.The struggle by Caenorhabditis elegans to maintain proteostasis during aging and diseaseAnimal modeling an oligodendrogliopathy--multiple system atrophyAlpha-Synuclein in Parkinson's Disease: From Pathogenetic Dysfunction to Potential Clinical ApplicationSpreading of pathology in neurodegenerative diseases: a focus on human studiesCuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and CytotoxicityAntidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophyα-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patientsSingle cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation.Towards translational therapies for multiple system atrophyReducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.Brain disposition of α-Synuclein: roles of brain barrier systems and implications for Parkinson's disease.Exploring Braak's Hypothesis of Parkinson's Disease.Pathogenesis of Parkinson disease--the gut-brain axis and environmental factors.Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts.Alpha-synuclein transfers from neurons to oligodendrocytes.Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophyGlucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein.The Interplay between Alpha-Synuclein Clearance and SpreadingAutophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.Transport of cargo from periphery to brain by circulating monocytes.Cyclosporin promotes neurorestoration and cell replacement therapy in pre-clinical models of Parkinson's diseaseα-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane.Prion-like propagation of protein aggregation and related therapeutic strategies.Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy.Neuropathological Staging of Brain Pathology in Sporadic Parkinson's disease: Separating the Wheat from the Chaff.Cellular mechanisms of protein aggregate propagationSynucleins: are they two-edged swords?The pathology roadmap in Parkinson disease.What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?
P2860
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P2860
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
@ast
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
@en
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
@nl
type
label
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
@ast
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
@en
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
@nl
prefLabel
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
@ast
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
@en
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
@nl
P2093
P2860
P3181
P1433
P1476
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
@en
P2093
Bengt Mattsson
Carla M Lema Tomé
Elodie Angot
Jennifer A Steiner
Peter Ekström
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0039465
P407
P577
2012-01-01T00:00:00Z