Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation
about
Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replicationFundamental Characteristics of AAA+ Protein Family Structure and FunctionArchaeal orthologs of Cdc45 and GINS form a stable complex that stimulates the helicase activity of MCMCMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome.Cdc45-induced loading of human RPA onto single-stranded DNA.Eukaryotic Replicative Helicase Subunit Interaction with DNA and Its Role in DNA Replication.Origin DNA Melting-An Essential Process with Divergent Mechanisms.Dpb11 may function with RPA and DNA to initiate DNA replicationThe eukaryotic CMG helicase pumpjack and integration into the replisome.DNA Interactions Probed by Hydrogen-Deuterium Exchange (HDX) Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Confirm External Binding Sites on the Minichromosomal Maintenance (MCM) Helicase.Chromosome Duplication in Saccharomyces cerevisiae.Mutations in CDC45, Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis.Staphylococcal SCCmec elements encode an active MCM-like helicase and thus may be replicative.Unravelling biological macromolecules with cryo-electron microscopy.New insights into the GINS complex explain the controversy between existing structural models.Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation.The RecJ2 protein in the thermophilic archaeon Thermoplasma acidophilum is a 3'-5' exonuclease that associates with a DNA replication complex.Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase.Pre-initiation complex assembly functions as a molecular switch that splits the Mcm2-7 double hexamer.Cryo-EM of dynamic protein complexes in eukaryotic DNA replication.Mechanisms and regulation of DNA replication initiation in eukaryotes.Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome?Watching cellular machinery in action, one molecule at a time.Mechanisms for initiating cellular DNA replication.A role for the base excision repair enzyme NEIL3 in replication-dependent repair of interstrand DNA cross-links derived from psoralen and abasic sites.Eukaryotic DNA Replication Fork.From structure to mechanism-understanding initiation of DNA replication.Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.Cdt1 stabilizes an open MCM ring for helicase loading.EMBuilder: A Template Matching-based Automatic Model-building Program for High-resolution Cryo-Electron Microscopy Maps.Two Archaeal RecJ Nucleases from Methanocaldococcus jannaschii Show Reverse Hydrolysis Polarity: Implication to Their Unique Function in Archaea.Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase.Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.The Cdc45/RecJ-like protein forms a complex with GINS and MCM, and is important for DNA replication in Thermococcus kodakarensis.Cryo-EM structure of a licensed DNA replication origin.Possible function of the second RecJ-like protein in stalled replication fork repair by interacting with Hef.Noise in the Machine: Alternative Pathway Sampling is the Rule During DNA Replication.The ring-shaped hexameric helicases that function at DNA replication forks.The Eukaryotic CMG Helicase at the Replication Fork: Emerging Architecture Reveals an Unexpected Mechanism.Architecture of the Saccharomyces cerevisiae Replisome.
P2860
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P2860
Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation
description
2016 nî lūn-bûn
@nan
2016 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Structure of the eukaryotic re ...... pjack motion for translocation
@ast
Structure of the eukaryotic re ...... pjack motion for translocation
@en
Structure of the eukaryotic re ...... pjack motion for translocation
@nl
type
label
Structure of the eukaryotic re ...... pjack motion for translocation
@ast
Structure of the eukaryotic re ...... pjack motion for translocation
@en
Structure of the eukaryotic re ...... pjack motion for translocation
@nl
prefLabel
Structure of the eukaryotic re ...... pjack motion for translocation
@ast
Structure of the eukaryotic re ...... pjack motion for translocation
@en
Structure of the eukaryotic re ...... pjack motion for translocation
@nl
P2093
P2860
P50
P3181
P356
P1476
Structure of the eukaryotic re ...... pjack motion for translocation
@en
P2093
Jingchuan Sun
Roxana Georgescu
P2860
P2888
P304
P3181
P356
10.1038/NSMB.3170
P407
P577
2016-02-08T00:00:00Z
P6179
1053369012