about
The ring-type polymerase sliding clamp familyAn interaction between DNA ligase I and proliferating cell nuclear antigen: implications for Okazaki fragment synthesis and joiningThe Eukaryotic Replisome Goes Under the MicroscopeThe RFC clamp loader: structure and functionNew insights into replisome fluidity during chromosome replicationStructure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocationThe architecture of a eukaryotic replisome.A TOPRIM domain in the crystal structure of the catalytic core of Escherichia coli primase confirms a structural link to DNA topoisomerasesCrystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase IIIThe Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader ComplexProteomic and genomic characterization of chromatin complexes at a boundaryReconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.A proposal: Evolution of PCNA's role as a marker of newly replicated DNAcDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogasterReplisome mechanics: insights into a twin DNA polymerase machineHuman CD4(+) T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1.Multiple competition reactions for RPA order the assembly of the DNA polymerase delta holoenzyme.Role of the adenovirus DNA-binding protein in in vitro adeno-associated virus DNA replication.RuvA is a sliding collar that protects Holliday junctions from unwinding while promoting branch migration.A slow ATP-induced conformational change limits the rate of DNA binding but not the rate of beta clamp binding by the escherichia coli gamma complex clamp loader.Replisome dynamics and use of DNA trombone loops to bypass replication blocks.Replisome mechanics: lagging strand events that influence speed and processivitySliding clamps: a (tail)ored fit.Mechanisms of DNA replication.Competitive processivity-clamp usage by DNA polymerases during DNA replication and repair.A tale of toroids in DNA metabolism.Interaction of the beta sliding clamp with MutS, ligase, and DNA polymerase I.CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication.Motors and switches: AAA+ machines within the replisome.Direct restart of a replication fork stalled by a head-on RNA polymerase.The sliding clamp of DNA polymerase III holoenzyme encircles DNA.Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation.Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork.DNA ligase: getting a grip to seal the deal.The Eukaryotic Replication Machine.Biochemical basis of SOS-induced mutagenesis in Escherichia coli: reconstitution of in vitro lesion bypass dependent on the UmuD'2C mutagenic complex and RecA protein.DNA replication: keep moving and don't mind the gap.Conserved residues in the delta subunit help the E. coli clamp loader, gamma complex, target primer-template DNA for clamp assembly.RecA acts as a switch to regulate polymerase occupancy in a moving replication fork.
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P50
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forsker
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wetenschapper
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հետազոտող
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M. O'Donnell
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M. O'Donnell
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Michael O'Donnell
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Michael O'Donnell
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Michael O'Donnell
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M. O'Donnell
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M. O'Donnell
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Michael O'Donnell
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Michael O'Donnell
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Michael O'Donnell
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M. O'Donnell
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M. O'Donnell
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M. O'Donnell
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Michael O'Donnell
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Michael O'Donnell
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Michael O'Donnell
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P106
P31
P496
0000-0001-9002-4214