Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
about
Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapyTherapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shiftmTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic InterventionsEmerging strategies to effectively target autophagy in cancerAutophagy in kidney health and disease.Die another way--non-apoptotic mechanisms of cell deathCytoprotection "gone astray": Nrf2 and its role in cancerThe synergistic effect of everolimus and chloroquine on endothelial cell number reduction is paralleled by increased apoptosis and reduced autophagy occurrencePUMA: a puzzle piece in chloroquine's antimelanoma activity.Addition of rapamycin and hydroxychloroquine to metronomic chemotherapy as a second line treatment results in high salvage rates for refractory metastatic solid tumors: a pilot safety and effectiveness analysis in a small patient cohortNrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinomaInhibition of autophagy potentiates atorvastatin-induced apoptotic cell death in human bladder cancer cells in vitro.DIRAS3 regulates the autophagosome initiation complex in dormant ovarian cancer cellsHexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cellsLoss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.The evolution of the TOR pathway and its role in cancer.Necroptotic signaling in adaptive and innate immunity.Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma.A curated census of autophagy-modulating proteins and small molecules: candidate targets for cancer therapy.Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting.The role for autophagy in cancer.Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells.Connexins: substrates and regulators of autophagyInhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitorsMacrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines.Atg7 cooperates with Pten loss to drive prostate cancer tumor growth.RIP3: a molecular switch for necrosis and inflammation.A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas.SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer.Ursolic Acid-Regulated Energy Metabolism-Reliever or Propeller of Ultraviolet-Induced Oxidative Stress and DNA Damage?Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway.Application and interpretation of current autophagy inhibitors and activators.Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy.Tumor vasculature: the Achilles' heel of cancer?The role and therapeutic potential of autophagy modulation in controlling virus-induced cell death.Autophagy: basic principles and relevance to transplant immunity.Transcriptional regulation of the stress response by mTOR.Autosis and autophagic cell death: the dark side of autophagyAutophagy as a pro-death pathway.
P2860
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P2860
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
@ast
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
@en
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
@nl
type
label
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
@ast
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
@en
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
@nl
prefLabel
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
@ast
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
@en
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
@nl
P2093
P2860
P50
P3181
P1433
P1476
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
@en
P2093
Alexandria Lau
Anahita Ghavami
Donna Zhang
Hsin-Yi Chen
Joshua D Rabinowitz
Kevin Bray
Mark Stein
Robert S DiPaola
Robin Mathew
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0041831
P407
P577
2012-07-26T00:00:00Z