Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.
about
Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatmentAutophagy in colorectal cancer: An important switch from physiology to pathologyTargeting autophagy in cancer management - strategies and developmentsChloroquine and hydroxychloroquine for cancer therapyTherapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shiftEmerging strategies to effectively target autophagy in cancerPro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling patPhosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-CellsGastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cellsAddition of rapamycin and hydroxychloroquine to metronomic chemotherapy as a second line treatment results in high salvage rates for refractory metastatic solid tumors: a pilot safety and effectiveness analysis in a small patient cohortInhibition of autophagy potentiates atorvastatin-induced apoptotic cell death in human bladder cancer cells in vitro.Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenibCombined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma.Autophagy: In the cROSshairs of cancer.The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death.The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.Melatonin combined with endoplasmic reticulum stress induces cell death via the PI3K/Akt/mTOR pathway in B16F10 melanoma cellsThe role for autophagy in cancer.Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells.Role of autophagy in the ω-3 long chain polyunsaturated fatty acid-induced death of lung cancer A549 cells.Anthricin Isolated from Anthriscus sylvestris (L.) Hoffm. Inhibits the Growth of Breast Cancer Cells by Inhibiting Akt/mTOR Signaling, and Its Apoptotic Effects Are Enhanced by Autophagy Inhibition.Recent insights into the function of autophagy in cancer.Human metastatic melanoma cell lines express high levels of growth hormone receptor and respond to GH treatment.Variants in autophagy-related genes and clinical characteristics in melanoma: a population-based studyPiperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death.Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cellsHydroxychloroquine facilitates autophagosome formation but not degradation to suppress the proliferation of cervical cancer SiHa cells.Inhibition of autophagy enhances the effects of the AKT inhibitor MK-2206 when combined with paclitaxel and carboplatin in BRAF wild-type melanoma.Phosphoinositide 3-kinases as accelerators and brakes of autophagy.Autophagy modulation: a target for cancer treatment development.Lysosomal Biology in Cancer.mTOR inhibitors in urinary bladder cancer.Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma.Lithium improves cell viability in psychosine-treated MO3.13 human oligodendrocyte cell line via autophagy activation.Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven MelanomaParkin and mitophagy in cancer.Research progress of hydroxychloroquine and autophagy inhibitors on cancer.Dynamic interplay between autophagic flux and Akt during melanoma progression in vitro.
P2860
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P2860
Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.
@ast
Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.
@en
Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.
@nl
type
label
Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.
@ast
Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.
@en
Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.
@nl
prefLabel
Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.
@ast
Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.
@en
Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.
@nl
P2860
P1433
P1476
Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.
@en
P2093
Janice M Mehnert
Xiaoqi Xie
P2860
P304
P356
10.1371/JOURNAL.PONE.0055096
P407
P50
P577
2013-01-30T00:00:00Z