Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2
about
Biochemical Genetic Pathways that Modulate Aging in Multiple SpeciesMitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals?The mitochondrial unfolded protein response—synchronizing genomesMitohormesisRestoration of mitochondria function as a target for cancer therapyThe mitochondrial unfolded protein response in mammalian physiologyMitochondrial proteostasis in the control of aging and longevityPhysiological consequences of complex II inhibition for aging, disease, and the mKATP channelMitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infectionTether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur proteinSurveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein ResponseProhibitin-mediated lifespan and mitochondrial stress implicate SGK-1, insulin/IGF and mTORC2 in C. elegansStress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and agingTransaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans.PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease.The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation?Loss of HMG-CoA reductase in C. elegans causes defects in protein prenylation and muscle mitochondria.SOD1, an unexpected novel target for cancer therapymTOR Signaling from Cellular Senescence to Organismal AgingNovel interactions between mitochondrial superoxide dismutases and the electron transport chain.D-beta-hydroxybutyrate extends lifespan in C. elegans.The paradox of mitochondrial dysfunction and extended longevity.The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegansVitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged miceIMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans.Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infectionCollaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans.Mitochondrial and cytoplasmic ROS have opposing effects on lifespan.Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).Mitochondrial maintenance failure in aging and role of sexual dimorphism.Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegansThe unpredictability of prolonged activation of stress response pathways.A chemical screen to identify inducers of the mitochondrial unfolded protein response in C. elegans.A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes.UPR(mt)-mediated cytoprotection and organismal aging.Mitochondrial Sulfide Quinone Oxidoreductase Prevents Activation of the Unfolded Protein Response in Hydrogen Sulfide.Metabolism and the UPR(mt).The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathwayMaintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response.Roles for ROS and hydrogen sulfide in the longevity response to germline loss in Caenorhabditis elegans.
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P2860
Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Protective coupling of mitocho ...... sis via the eIF2α kinase GCN-2
@ast
Protective coupling of mitocho ...... sis via the eIF2α kinase GCN-2
@en
Protective coupling of mitocho ...... sis via the eIF2α kinase GCN-2
@nl
type
label
Protective coupling of mitocho ...... sis via the eIF2α kinase GCN-2
@ast
Protective coupling of mitocho ...... sis via the eIF2α kinase GCN-2
@en
Protective coupling of mitocho ...... sis via the eIF2α kinase GCN-2
@nl
prefLabel
Protective coupling of mitocho ...... sis via the eIF2α kinase GCN-2
@ast
Protective coupling of mitocho ...... sis via the eIF2α kinase GCN-2
@en
Protective coupling of mitocho ...... sis via the eIF2α kinase GCN-2
@nl
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Protective coupling of mitocho ...... sis via the eIF2α kinase GCN-2
@en
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Amrita M Nargund
Brooke M Baker
Cole M Haynes
Tiffany Sun
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10.1371/JOURNAL.PGEN.1002760
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2012-01-01T00:00:00Z