Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4
about
Biological Transmission of Arboviruses: Reexamination of and New Insights into Components, Mechanisms, and Unique Traits as Well as Their Evolutionary TrendsKissing-loop interaction between 5' and 3' ends of tick-borne Langat virus genome 'bridges the gap' between mosquito- and tick-borne flaviviruses in mechanisms of viral RNA cyclization: applications for virus attenuation and vaccine developmentA three-dimensional comparison of tick-borne flavivirus infection in mammalian and tick cell linesTick-borne flavivirus infection in Ixodes scapularis larvae: development of a novel method for synchronous viral infection of ticksDual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral ClearanceRecovery of West Nile Virus Envelope Protein Domain III Chimeras with Altered Antigenicity and Mouse VirulenceReplacement of the ectodomains of the hemagglutinin-neuraminidase and fusion glycoproteins of recombinant parainfluenza virus type 3 (PIV3) with their counterparts from PIV2 yields attenuated PIV2 vaccine candidatesChimeric yellow fever/dengue virus as a candidate dengue vaccine: quantitation of the dengue virus-specific CD8 T-cell responseReplacement of the F and G proteins of respiratory syncytial virus (RSV) subgroup A with those of subgroup B generates chimeric live attenuated RSV subgroup B vaccine candidates.Chimeric Dengue 2 PDK-53/West Nile NY99 Viruses Retain the Phenotypic Attenuation Markers of the Candidate PDK-53 Vaccine Virus and Protect Mice against Lethal Challenge with West Nile VirusTick-Borne Langat/Mosquito-Borne Dengue Flavivirus Chimera, a Candidate Live Attenuated Vaccine for Protection against Disease Caused by Members of the Tick-Borne Encephalitis Virus Complex: Evaluation in Rhesus Monkeys and in MosquitoesWest Nile virus/dengue type 4 virus chimeras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacyInhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonistA tick-borne Langat virus mutant that is temperature sensitive and host range restricted in neuroblastoma cells and lacks neuroinvasiveness for immunodeficient miceVaccine candidates for dengue virus type 1 (DEN1) generated by replacement of the structural genes of rDEN4 and rDEN4Delta30 with those of DEN1Evaluation of the Langat/dengue 4 chimeric virus as a live attenuated tick-borne encephalitis vaccine for safety and immunogenicity in healthy adult volunteersComparative Neuropathogenesis and Neurovirulence of Attenuated Flaviviruses in Nonhuman PrimatesEvaluation of St. Louis encephalitis virus/dengue virus type 4 antigenic chimeric viruses in mice and rhesus monkeysIdentification of genetic determinants of a tick-borne flavivirus associated with host-specific adaptation and pathogenicityNeuropathogenesis and Neurovirulence of Live Flaviviral Vaccines in MonkeysCellular Inflammatory Response to Flaviviruses in the Central Nervous System of a Primate HostEfficient, trans-complementing packaging systems for chimeric, pseudoinfectious dengue 2/yellow fever virusesIdentification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulatorChanges in the Proteome of Langat-Infected Ixodes scapularis ISE6 Cells: Metabolic Pathways Associated with Flavivirus InfectionJapanese encephalitis virus vaccine candidates generated by chimerization with dengue virus type 4The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3' non-coding region of the genome.Differential salivary gland transcript expression profile in Ixodes scapularis nymphs upon feeding or flavivirus infectionStructural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes.High-throughput automated image analysis of neuroinflammation and neurodegeneration enables quantitative assessment of virus neurovirulence.Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype.Chimeric tick-borne encephalitis/dengue virus is attenuated in Ixodes scapularis ticks and Aedes aegypti mosquitoes.Replacement of the 3' untranslated variable region of mosquito-borne dengue virus with that of tick-borne Langat virus does not alter vector specificity.Vaccination with dengue virus-like particles induces humoral and cellular immune responses in mice.MicroRNA targeting of neurotropic flavivirus: effective control of virus escape and reversion to neurovirulent phenotype.Microarray hybridization for assessment of the genetic stability of chimeric West Nile/dengue 4 virusMicroRNA-based control of tick-borne flavivirus neuropathogenesis: Challenges and perspectives.Toll-like receptor 7 suppresses virus replication in neurons but does not affect viral pathogenesis in a mouse model of Langat virus infection.The Emerging Duck Flavivirus Is Not Pathogenic for Primates and Is Highly Sensitive to Mammalian Interferon Antiviral Signaling.Advances in vaccination against tick-borne encephalitis.A chimeric dengue virus vaccine using Japanese encephalitis virus vaccine strain SA14-14-2 as backbone is immunogenic and protective against either parental virus in mice and nonhuman primates.
P2860
Q24289112-DCDEE607-5399-4EF9-A97F-DAA02B82D559Q24289179-249C2764-5C1C-4B70-B204-025668F304B4Q24457196-C813C5C0-4D82-47B6-B01C-0D089E616BBDQ24457212-33462D90-0639-4F31-86B3-CF4477DB2238Q26700108-2C28C73D-1480-4534-9956-2612BC0CFAA7Q27469118-7FCFB787-B358-4B36-8635-842B3BCB43E6Q27469676-12741B81-0590-455F-9BE8-8CF7B079AED0Q27469691-77A814CA-A6A1-40B8-91C5-0E3EFA5A07DCQ27469749-325568D8-22AC-4150-A33B-29102AEEE989Q27469831-63D3D482-6E1E-44A1-9C33-DEEF68653BB3Q27469955-E24EBA80-789B-4374-B7BA-EEA6D1CCD04BQ27471660-D025EF90-FC2A-46E4-8732-D257CD71F4BEQ27472136-31301EEC-4CA4-4B44-A351-5E105738CA37Q27472824-2107C8D5-5C8D-4EE4-94D4-90E1F61EE2F9Q27478162-62A3FFA1-45D4-4D28-AC5A-D9B4E8927AC6Q27485433-D4C027A6-D09F-40E2-98ED-3E0436BC28D6Q27486117-3BB1184E-AE22-4370-A569-750C674DE947Q27487013-B15F0C41-64C4-43AA-8B3A-049D6CCC7D34Q27487383-D80130AE-9C39-41D0-AD30-0FADDF57CE28Q27488399-9DF2A88F-E042-4B9F-B929-D81C25DE8B06Q27489646-E0A2A572-D234-4133-A110-CC4C16100B0DQ27491035-BDFD104E-2FFA-438B-9F34-C12C767A5237Q28476726-2B1792B6-6B6F-4A19-89BE-32A528216ED4Q28550057-94ABE9E2-2715-427E-886C-33ECF0FD11B6Q33852635-6ED2C45C-830B-4F35-82DD-4F5C10C75248Q34036778-8121E283-904E-4084-9152-2664828742A4Q34152051-8BB58B19-2CF5-4A2C-9EBF-D404FDABAD7EQ34218526-FCB56548-EC9B-4C6C-B846-716AF53CF857Q34384833-E18EBFD6-0107-4155-BBEC-B7EEE96B9D4DQ34529812-57041480-B09F-488A-A11C-A0916D67CEEAQ35046285-FC9E3C40-9733-40B5-A239-73CEAA1FA8E6Q35097570-3B8BED77-90D3-46ED-AF52-4DA8D24C6687Q35128995-F7EB8800-ACF7-441D-91B9-C42F3EF988A2Q35943367-12918B12-460E-48E8-AFF6-375E500EE696Q36136167-6EADFB9D-25E5-4A02-9DC5-FA7E070BA356Q36599056-4F4C8B2E-9197-4D3D-867C-492B038DC84EQ37006727-91AE9C16-232B-45F3-830A-81760876C225Q37073267-C4F366D8-4D34-486C-BC25-A1FFA2DF8A46Q37194776-6B289D41-95F3-40C5-AE11-634654ECAE42Q37336762-3FB934ED-7630-44EF-ACD9-1639766E4D1A
P2860
Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4
description
1998 nî lūn-bûn
@nan
1998 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Attenuation of the Langat tick ...... borne flavivirus dengue type 4
@ast
Attenuation of the Langat tick ...... borne flavivirus dengue type 4
@en
Attenuation of the Langat tick ...... borne flavivirus dengue type 4
@nl
type
label
Attenuation of the Langat tick ...... borne flavivirus dengue type 4
@ast
Attenuation of the Langat tick ...... borne flavivirus dengue type 4
@en
Attenuation of the Langat tick ...... borne flavivirus dengue type 4
@nl
prefLabel
Attenuation of the Langat tick ...... borne flavivirus dengue type 4
@ast
Attenuation of the Langat tick ...... borne flavivirus dengue type 4
@en
Attenuation of the Langat tick ...... borne flavivirus dengue type 4
@nl
P2860
P356
P1476
Attenuation of the Langat tick ...... borne flavivirus dengue type 4
@en
P2093
P2860
P304
P356
10.1073/PNAS.95.4.1746
P407
P577
1998-02-17T00:00:00Z