The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3' non-coding region of the genome.
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The role of viral persistence in flavivirus biologyKissing-loop interaction between 5' and 3' ends of tick-borne Langat virus genome 'bridges the gap' between mosquito- and tick-borne flaviviruses in mechanisms of viral RNA cyclization: applications for virus attenuation and vaccine developmentA full-length infectious cDNA clone of Zika virus from the 2015 epidemic in Brazil as a genetic platform for studies of virus-host interactions and vaccine developmentConcurrent micro-RNA mediated silencing of tick-borne flavivirus replication in tick vector and in the brain of vertebrate hostSynergistic interactions between the NS3(hel) and E proteins contribute to the virulence of dengue virus type 1The 5' and 3' Untranslated Regions of the Flaviviral Genome.Exploring of primate models of tick-borne flaviviruses infection for evaluation of vaccines and drugs efficacy.Synergistic Internal Ribosome Entry Site/MicroRNA-Based Approach for Flavivirus Attenuation and Live Vaccine Development.A critical determinant of neurological disease associated with highly pathogenic tick-borne flavivirus in miceSilencing of neurotropic flavivirus replication in the central nervous system by combining multiple microRNA target insertions in two distinct viral genome regionsNsp9 and Nsp10 contribute to the fatal virulence of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China.A single amino acid in nonstructural protein NS4B confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis.Attenuation of virulence in an apicomplexan hemoparasite results in reduced genome diversity at the population level.Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype.Comparative transcriptome analysis of geographically distinct virulent and attenuated Babesia bovis strains reveals similar gene expression changes through attenuationChimeric tick-borne encephalitis/dengue virus is attenuated in Ixodes scapularis ticks and Aedes aegypti mosquitoes.Dual miRNA targeting restricts host range and attenuates neurovirulence of flaviviruses.MicroRNA targeting of neurotropic flavivirus: effective control of virus escape and reversion to neurovirulent phenotype.MicroRNA-based control of tick-borne flavivirus neuropathogenesis: Challenges and perspectives.Substitution of the premembrane and envelope protein genes of Modoc virus with the homologous sequences of West Nile virus generates a chimeric virus that replicates in vertebrate but not mosquito cellsMolecular evolution and epidemiology of four serotypes of dengue virus in Thailand from 1973 to 2007.Viral Determinants of Virulence in Tick-Borne Flaviviruses
P2860
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P2860
The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3' non-coding region of the genome.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The neurovirulence and neuroin ...... n-coding region of the genome.
@ast
The neurovirulence and neuroin ...... n-coding region of the genome.
@en
The neurovirulence and neuroin ...... n-coding region of the genome.
@nl
type
label
The neurovirulence and neuroin ...... n-coding region of the genome.
@ast
The neurovirulence and neuroin ...... n-coding region of the genome.
@en
The neurovirulence and neuroin ...... n-coding region of the genome.
@nl
prefLabel
The neurovirulence and neuroin ...... n-coding region of the genome.
@ast
The neurovirulence and neuroin ...... n-coding region of the genome.
@en
The neurovirulence and neuroin ...... n-coding region of the genome.
@nl
P2093
P2860
P1433
P1476
The neurovirulence and neuroin ...... n-coding region of the genome.
@en
P2093
Alexander A Rumyantsev
Alexander G Pletnev
Amber R Engel
Brian Heiss
Brian R Murphy
James M Speicher
Olga A Maximova
P2860
P304
P356
10.1016/J.VIROL.2010.06.014
P407
P577
2010-07-01T00:00:00Z