IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells
about
Properties and use of novel replication-competent vectors based on Semliki Forest virusNovel chikungunya vaccine candidate with an IRES-based attenuation and host range alteration mechanismCross-protective immunity against o'nyong-nyong virus afforded by a novel recombinant chikungunya vaccineExtended Preclinical Safety, Efficacy and Stability Testing of a Live-attenuated Chikungunya Vaccine CandidateA vaccine candidate for eastern equine encephalitis virus based on IRES-mediated attenuationVaccines for Venezuelan equine encephalitisType I interferon reaction to viral infection in interferon-competent, immortalized cell lines from the African fruit bat Eidolon helvumSynergistic Internal Ribosome Entry Site/MicroRNA-Based Approach for Flavivirus Attenuation and Live Vaccine Development.Double subgenomic alphaviruses expressing multiple fluorescent proteins using a Rhopalosiphum padi virus internal ribosome entry site elementA novel live-attenuated vaccine candidate for mayaro Fever.Attenuation of Chikungunya virus vaccine strain 181/clone 25 is determined by two amino acid substitutions in the E2 envelope glycoprotein.IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safetyVenezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype.Control of the rescue and replication of Semliki Forest virus recombinants by the insertion of miRNA target sequences.Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype.Chimeric Chikungunya viruses are nonpathogenic in highly sensitive mouse models but efficiently induce a protective immune response.Deciphering the protective role of adaptive immunity to CHIKV/IRES a novel candidate vaccine against Chikungunya in the A129 mouse model.Attenuation of rabies virus replication and virulence by picornavirus internal ribosome entry site elementsIRES-based Venezuelan equine encephalitis vaccine candidate elicits protective immunity in mice.Internal ribosome entry site-based attenuation of a flavivirus candidate vaccine and evaluation of the effect of beta interferon coexpression on vaccine propertiesDesign and Validation of Novel Chikungunya Virus Protease Inhibitors.Interferon-stimulated poly(ADP-Ribose) polymerases are potent inhibitors of cellular translation and virus replicationVenezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions.The amino-terminal domain of alphavirus capsid protein is dispensable for viral particle assembly but regulates RNA encapsidation through cooperative functions of its subdomains.β-D-N(4)-hydroxycytidine is a potent anti-alphavirus compound that induces high level of mutations in viral genome.
P2860
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P2860
IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
IRES-dependent replication of ...... replicating in mosquito cells
@ast
IRES-dependent replication of ...... replicating in mosquito cells
@en
IRES-dependent replication of ...... replicating in mosquito cells
@nl
type
label
IRES-dependent replication of ...... replicating in mosquito cells
@ast
IRES-dependent replication of ...... replicating in mosquito cells
@en
IRES-dependent replication of ...... replicating in mosquito cells
@nl
prefLabel
IRES-dependent replication of ...... replicating in mosquito cells
@ast
IRES-dependent replication of ...... replicating in mosquito cells
@en
IRES-dependent replication of ...... replicating in mosquito cells
@nl
P2093
P2860
P50
P1433
P1476
IRES-dependent replication of ...... replicating in mosquito cells
@en
P2093
Eugenia Volkova
Justin R Darwin
Naomi L Forrester
P2860
P356
10.1016/J.VIROL.2008.04.020
P407
P577
2008-07-20T00:00:00Z