Hyperthermostable protein structure maintained by intra and inter-helix ion-pairs in archaeal O6-methylguanine-DNA methyltransferase
about
Genome analysis and genome-wide proteomics of Thermococcus gammatolerans, the most radioresistant organism known amongst the ArchaeaCrystal structure of the human O(6)-alkylguanine-DNA alkyltransferaseThe first crystal structure of archaeal aldolase. Unique tetrameric structure of 2-deoxy-d-ribose-5-phosphate aldolase from the hyperthermophilic archaea Aeropyrum pernixStructural Basis for Thermostability of -Glycosidase from the Thermophilic Eubacterium Thermus nonproteolyticus HG102Crystal structure of highly thermostable glycerol kinase from a hyperthermophilic archaeon in a dimeric formStructural Basis ofO6-Alkylguanine Recognition by a Bacterial Alkyltransferase-like DNA Repair ProteinBiochemical and Structural Studies of the Mycobacterium tuberculosis O6-Methylguanine Methyltransferase and Mutated VariantsHyperthermophilic enzymes: sources, uses, and molecular mechanisms for thermostabilityRole of N-terminal extension of Bacillus stearothermophilus RNase H2 and C-terminal extension of Thermotoga maritima RNase H2.Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine.Using structural motif templates to identify proteins with DNA binding function.A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities.Catalyzing "hot" reactions: enzymes from hyperthermophilic Archaea.Widespread disulfide bonding in proteins from thermophilic archaeaDNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapyStructure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable proteinDirect reversal of DNA alkylation damage.Implication for buried polar contacts and ion pairs in hyperthermostable enzymes.DNA base repair--recognition and initiation of catalysis.Model organisms for genetics in the domain Archaea: methanogens, halophiles, Thermococcales and Sulfolobales.Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools.Molecular bases of thermophily in hyperthermophiles.Genome stability: recent insights in the topoisomerase reverse gyrase and thermophilic DNA alkyltransferase.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability.A DNA ligase from a hyperthermophilic archaeon with unique cofactor specificity.Identifying DNA-binding proteins using structural motifs and the electrostatic potential.Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase.Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine.Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus.Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase.Comparative analyses of the conformational stability of a hyperthermophilic protein and its mesophilic counterpart.Novel DNA repair alkyltransferase from Caenorhabditis elegans.The unique pentagonal structure of an archaeal Rubisco is essential for its high thermostability.Every OGT Is Illuminated … by Fluorescent and Synchrotron Lights.Archaeal RNA polymerase arrests transcription at DNA lesions.
P2860
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P2860
Hyperthermostable protein structure maintained by intra and inter-helix ion-pairs in archaeal O6-methylguanine-DNA methyltransferase
description
1999 nî lūn-bûn
@nan
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Hyperthermostable protein stru ...... lguanine-DNA methyltransferase
@ast
Hyperthermostable protein stru ...... lguanine-DNA methyltransferase
@en
Hyperthermostable protein stru ...... lguanine-DNA methyltransferase
@nl
type
label
Hyperthermostable protein stru ...... lguanine-DNA methyltransferase
@ast
Hyperthermostable protein stru ...... lguanine-DNA methyltransferase
@en
Hyperthermostable protein stru ...... lguanine-DNA methyltransferase
@nl
prefLabel
Hyperthermostable protein stru ...... lguanine-DNA methyltransferase
@ast
Hyperthermostable protein stru ...... lguanine-DNA methyltransferase
@en
Hyperthermostable protein stru ...... lguanine-DNA methyltransferase
@nl
P2093
P356
P1476
Hyperthermostable protein stru ...... lguanine-DNA methyltransferase
@en
P2093
H Hashimoto
M Nishioka
S Fujiwara
P304
P356
10.1006/JMBI.1999.3100
P407
P577
1999-09-24T00:00:00Z