Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis
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Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH).3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureusThe 1.3-Angstrom-resolution crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniaeBacterial lipids: metabolism and membrane homeostasisInhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanismIdentification and analysis of the acyl carrier protein (ACP) docking site on beta-ketoacyl-ACP synthase IIICrystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase IIIType I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structureProbing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substratesStructure of 3-oxoacyl-(acyl-carrier protein) synthase II fromThermus thermophilusHB8Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzymeStructure of FabH and factors affecting the distribution of branched fatty acids inMicrococcus luteusStructural Characterisation of the Beta-Ketoacyl-Acyl Carrier Protein Synthases, FabF and FabH, of Yersinia pestisCrystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediatesStructural classification and properties of ketoacyl synthases.Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH).Engineered fatty acid biosynthesis in Streptomyces by altered catalytic function of beta-ketoacyl-acyl carrier protein synthase III.Response of Bacillus subtilis to cerulenin and acquisition of resistance.Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureusProbing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.2,5-dialkylresorcinol biosynthesis in Pseudomonas aurantiaca: novel head-to-head condensation of two fatty acid-derived precursorsRoles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae.Novel antigens of Helicobacter pylori correspond to ulcer-related antibody pattern of sera from infected patientsThe enzymology of combinatorial biosynthesis.Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs.Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents.Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering.Phloretin Exerts Anti-Tuberculosis Activity and Suppresses Lung Inflammation.Coexpression of genetically engineered 3-ketoacyl-ACP synthase III (fabH) and polyhydroxyalkanoate synthase (phaC) genes leads to short-chain-length-medium-chain-length polyhydroxyalkanoate copolymer production from glucose in Escherichia coli JM109An orthogonal purification strategy for isolating crosslinked domains of modular synthases.Alteration of reaction and substrate specificity of a bacterial type III polyketide synthase by site-directed mutagenesisMutations in the fatty acid elongation 1 gene are associated with a loss of beta-ketoacyl-CoA synthase activity in low erucic acid rapeseed.Properties and substrate specificity of RppA, a chalcone synthase-related polyketide synthase in Streptomyces griseus.The influence of conserved aromatic residues in 3-hydroxy-3-methylglutaryl-CoA synthase.Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase: crystal structure and mechanism.Prediction of inter domain interactions in modular polyketide synthases by docking and correlated mutation analysis.Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases.In vitro reconstitution of α-pyrone ring formation in myxopyronin biosynthesis† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc01013f.
P2860
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P2860
Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Crystal structure of beta-keto ...... terial fatty acid biosynthesis
@ast
Crystal structure of beta-keto ...... terial fatty acid biosynthesis
@en
Crystal structure of beta-keto ...... terial fatty acid biosynthesis
@nl
type
label
Crystal structure of beta-keto ...... terial fatty acid biosynthesis
@ast
Crystal structure of beta-keto ...... terial fatty acid biosynthesis
@en
Crystal structure of beta-keto ...... terial fatty acid biosynthesis
@nl
prefLabel
Crystal structure of beta-keto ...... terial fatty acid biosynthesis
@ast
Crystal structure of beta-keto ...... terial fatty acid biosynthesis
@en
Crystal structure of beta-keto ...... terial fatty acid biosynthesis
@nl
P2093
P2860
P921
P356
P1476
Crystal structure of beta-keto ...... terial fatty acid biosynthesis
@en
P2093
A K Konstantinidis
C A Janson
C Silverman
J Lonsdale
S Khandekar
S S Abdel-Meguid
P2860
P304
P356
10.1074/JBC.274.51.36465
P407
P577
1999-12-17T00:00:00Z