Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism
about
Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabHCloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strainDiscovery of FabH/FabF inhibitors from natural products.1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureusDiscovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic propertiesThe 1.3-Angstrom-resolution crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniaeBacterial lipids: metabolism and membrane homeostasisCrystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase IIIX-Ray Crystal Structure of Mycobacterium tuberculosis β-Ketoacyl Acyl Carrier Protein Synthase II (mtKasB)Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthaseType I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structureStructural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B SynthaseStructure-assisted discovery of an aminothiazole derivative as a lead molecule for inhibition of bacterial fatty-acid synthesisStructure of 3-oxoacyl-(acyl-carrier protein) synthase II fromThermus thermophilusHB8Inhibition of the fungal fatty acid synthase type I multienzyme complexCrystal Structures of Mycobacterium tuberculosis KasA Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by ThiolactomycinBiochemical and Structural Basis for Inhibition of Enterococcus faecalis Hydroxymethylglutaryl-CoA Synthase, mvaS, by HymeglusinCrystal Structures of Xanthomonas campestris OleA Reveal Features That Promote Head-to-Head Condensation of Two Long-Chain Fatty AcidsStructural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target from Mycobacterium TuberculosisStructural insights into bacterial resistance to ceruleninUsing modern tools to probe the structure-function relationship of fatty acid synthasesAntibacterial targets in fatty acid biosynthesisStructural Characterisation of the Beta-Ketoacyl-Acyl Carrier Protein Synthases, FabF and FabH, of Yersinia pestisFatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infectionPurification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasBMycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosisDissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae.Determination of selectivity and efficacy of fatty acid synthesis inhibitors.Mass spectrometry-based systems approach for identification of inhibitors of Plasmodium falciparum fatty acid synthaseEnzymes of type II fatty acid synthesis and apicoplast differentiation and division in Eimeria tenella.Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents.Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin.The in vivo structure of biological membranes and evidence for lipid domains.Challenges of antibacterial discoveryIdentification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH).Functional replacement of the FabA and FabB proteins of Escherichia coli fatty acid synthesis by Enterococcus faecalis FabZ and FabF homologues.Accumulation of polyhydroxyalkanoic acid containing large amounts of unsaturated monomers in Pseudomonas fluorescens BM07 utilizing saccharides and its inhibition by 2-bromooctanoic acid.Escherichia coli FadR positively regulates transcription of the fabB fatty acid biosynthetic gene.A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli.
P2860
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P2860
Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Inhibition of beta-ketoacyl-ac ...... lenin. Structure and mechanism
@ast
Inhibition of beta-ketoacyl-ac ...... lenin. Structure and mechanism
@en
Inhibition of beta-ketoacyl-ac ...... lenin. Structure and mechanism
@nl
type
label
Inhibition of beta-ketoacyl-ac ...... lenin. Structure and mechanism
@ast
Inhibition of beta-ketoacyl-ac ...... lenin. Structure and mechanism
@en
Inhibition of beta-ketoacyl-ac ...... lenin. Structure and mechanism
@nl
prefLabel
Inhibition of beta-ketoacyl-ac ...... lenin. Structure and mechanism
@ast
Inhibition of beta-ketoacyl-ac ...... lenin. Structure and mechanism
@en
Inhibition of beta-ketoacyl-ac ...... lenin. Structure and mechanism
@nl
P2093
P2860
P356
P1476
Inhibition of beta-ketoacyl-ac ...... lenin. Structure and mechanism
@en
P2093
P2860
P304
P356
10.1074/JBC.M007101200
P407
P577
2001-03-02T00:00:00Z