Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding
about
The modified human DNA repair enzyme O(6)-methylguanine-DNA methyltransferase is a negative regulator of estrogen receptor-mediated transcription upon alkylation DNA damageAda response - a strategy for repair of alkylated DNA in bacteriaEmerging critical roles of Fe-S clusters in DNA replication and repair.Flipping of alkylated DNA damage bridges base and nucleotide excision repairStructural Basis ofO6-Alkylguanine Recognition by a Bacterial Alkyltransferase-like DNA Repair ProteinBiochemical and Structural Studies of the Mycobacterium tuberculosis O6-Methylguanine Methyltransferase and Mutated VariantsGenome-wide analysis of alternative splicing in Volvox carteriThe SpoIIQ-SpoIIIAH complex of Clostridium difficile controls forespore engulfment and late stages of gene expression and spore morphogenesisAtomic Insight into the Altered O6-Methylguanine-DNA Methyltransferase Protein Architecture in Gastric CancerMechanism to trigger unfolding in O(6) -alkylguanine-DNA alkyltransferase.A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGTDetection of protein catalytic residues at high precision using local network properties.Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases.Genetic profiling of a rare condition: co-occurrence of albinism and multiple primary melanoma in a Caucasian family.A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities.AdoMet-dependent methylation, DNA methyltransferases and base flipping.Insight into the cooperative DNA binding of the O⁶-alkylguanine DNA alkyltransferase.Engineering the elongation factor Tu for efficient selenoprotein synthesis.Formation, repair, and genotoxic properties of bulky DNA adducts formed from tobacco-specific nitrosamines.Development of a split SNAP-tag protein complementation assay for visualization of protein-protein interactions in living cells.Engineering substrate specificity of O6-alkylguanine-DNA alkyltransferase for specific protein labeling in living cells.S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesisAlkyltransferase-like proteins: molecular switches between DNA repair pathways.Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activityCross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutaneDNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapyHuman variants of O6-alkylguanine-DNA alkyltransferase.Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable proteinCooperative cluster formation, DNA bending and base-flipping by O6-alkylguanine-DNA alkyltransferase.Direct reversal of DNA alkylation damage.Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase.S-alkylthiolation of O6-methylguanine-DNA-methyltransferase (MGMT) to sensitize cancer cells to anticancer therapy.Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine.Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide.Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality.Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine.Kinetics of O(6)-pyridyloxobutyl-2'-deoxyguanosine repair by human O(6)-alkylguanine DNA alkyltransferase.Selective labeling of proteins with chemical probes in living cells.Topologies of complexes containing O6-alkylguanine-DNA alkyltransferase and DNA.Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides.
P2860
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P2860
Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding
description
2000 nî lūn-bûn
@nan
2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Active and alkylated human AGT ...... and extrahelical base binding
@ast
Active and alkylated human AGT ...... and extrahelical base binding
@en
Active and alkylated human AGT ...... and extrahelical base binding
@nl
type
label
Active and alkylated human AGT ...... and extrahelical base binding
@ast
Active and alkylated human AGT ...... and extrahelical base binding
@en
Active and alkylated human AGT ...... and extrahelical base binding
@nl
prefLabel
Active and alkylated human AGT ...... and extrahelical base binding
@ast
Active and alkylated human AGT ...... and extrahelical base binding
@en
Active and alkylated human AGT ...... and extrahelical base binding
@nl
P2093
P2860
P356
P1433
P1476
Active and alkylated human AGT ...... and extrahelical base binding
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/19.7.1719
P407
P577
2000-04-01T00:00:00Z