A functional hot spot for antigen recognition in a superagonist TCR/MHC complex
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Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivSurface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivityStructure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex ComplexesCrystal structure of a complete ternary complex of TCR, superantigen and peptide-MHCStructural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptorSingle MHC Mutation Eliminates Enthalpy Associated with T Cell Receptor BindingDistinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientationT Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular FlexibilityThe Structure and Stability of the Monomorphic HLA-G Are Influenced by the Nature of the Bound PeptideConformational Melding Permits a Conserved Binding Geometry in TCR Recognition of Foreign and Self Molecular MimicsA Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T CellsThe Peptide-Receptive Transition State of MHC Class I Molecules: Insight from Structure and Molecular DynamicsA molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cellsT-cell receptor V(alpha) usage by effector CD4+Vbeta11+ T cells mediating graft-versus-host disease directed to minor histocompatibility antigens.New design of MHC class II tetramers to accommodate fundamental principles of antigen presentationThe effect of mutations on the alloreactive T cell receptor/peptide-MHC interface structure: a molecular dynamics study.Engineering higher affinity T cell receptors using a T cell display system.TCRep 3D: an automated in silico approach to study the structural properties of TCR repertoires.Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and functionDesign of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses.Survey of the year 2000 commercial optical biosensor literature.Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions.A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor controlQuantitative Analysis of the Association Angle between T-cell Receptor Vα/Vβ Domains Reveals Important Features for Epitope RecognitionForce-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells.Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitis.Identification of a crucial energetic footprint on the alpha1 helix of human histocompatibility leukocyte antigen (HLA)-A2 that provides functional interactions for recognition by tax peptide/HLA-A2-specific T cell receptors.CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation.Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.Structural and kinetic basis for heightened immunogenicity of T cell vaccines.Crystal structures of T cell receptor (beta) chains related to rheumatoid arthritis.Structural determinants of T-cell receptor bias in immunity.Cross-reactivity of T cells and its role in the immune systemRole of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies.Structure-Based, Rational Design of T Cell Receptors.Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes.Different strategies adopted by K(b) and L(d) to generate T cell specificity directed against their respective bound peptides.T cell sensitivity and the outcome of viral infection.Mediation of T-cell activation by actin meshworks
P2860
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P2860
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex
description
2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex
@ast
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex
@en
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex
@nl
type
label
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex
@ast
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex
@en
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex
@nl
prefLabel
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex
@ast
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex
@en
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex
@nl
P2093
P1433
P1476
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex
@en
P2093
I A Wilson
K C Garcia
M G Rudolph
P304
P356
10.1016/S1074-7613(00)80178-8
P407
P577
2000-03-01T00:00:00Z